Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2.

Publication Type:

Journal Article


The New England journal of medicine, Volume 362, Issue 5, p.427-39 (2010)


2010, Acyclovir, Adolescent, Adult, AIDS-Related Opportunistic Infections, Antiviral Agents, CD4 Lymphocyte Count, Center-Authored Paper, Female, Follow-Up Studies, Herpes Genitalis, Herpesvirus 2, Human, HIV Infections, HIV-1, Humans, Intention to Treat Analysis, Kaplan-Meier Estimate, Male, Patient Compliance, PREGNANCY, RNA, Viral, Unsafe Sex, Vaccine and Infectious Disease Division, Young Adult


Most persons who are infected with human immunodeficiency virus type 1 (HIV-1) are also infected with herpes simplex virus type 2 (HSV-2), which is frequently reactivated and is associated with increased plasma and genital levels of HIV-1. Therapy to suppress HSV-2 reduces the frequency of reactivation of HSV-2 as well as HIV-1 levels, suggesting that suppression of HSV-2 may reduce the risk of transmission of HIV-1.