Activation of NF-kappaB by palmitate in endothelial cells: a key role for NADPH oxidase-derived superoxide in response to TLR4 activation.

Publication Type:

Journal Article

Authors:

Maloney, Ezekiel; Sweet, Ian R; Hockenbery, David M; Pham, Matilda; Rizzo, Norma O; Tateya, Sanshiro; Handa, Priya; Schwartz, Michael W; Kim, Francis

Source:

Arteriosclerosis, thrombosis, and vascular biology, Volume 29, Issue 9, p.1370-5 (2009)

Keywords:

2009, Animals, Aorta, Thoracic, Bone Morphogenetic Protein 4, Cells, Cultured, Center-Authored Paper, Clinical Research Division, Dietary Fats, Endothelial Cells, Humans, I-kappa B Proteins, Intercellular Adhesion Molecule-1, Interleukin-1 Receptor-Associated Kinases, Interleukin-6, MICE, Mice, Inbred C57BL, Mice, Knockout, Myeloid Differentiation Factor 88, NADPH Oxidase, NF-kappa B, Onium Compounds, Palmitic Acid, PHOSPHORYLATION, RNA Interference, RNA, Messenger, Signal Transduction, Superoxide Dismutase, Superoxides, Time Factors, Toll-Like Receptor 4

Abstract:

We investigated whether NADPH oxidase-dependent production of superoxide contributes to activation of NF-kappaB in endothelial cells by the saturated free fatty acid palmitate.

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