Accelerated suppression of primary EBV infection in HIV-infected infants initiating lopinavir/ritonavir-based versus nevirapine-based combination antiretroviral therapy.

Publication Type:

Journal Article

Authors:

Slyker, Jennifer A; Casper, Corey; Tapia, Kenneth; Richardson, Barbra; Bunts, Lisa; Huang, Meei-Li; Wamalwa, Dalton; Benki-Nugent, Sarah; John-Stewart, Grace

Source:

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2014)

Keywords:

2014, Center-Authored Paper, Clinical Research Division, March 2014, Public Health Sciences Division, Vaccine and Infectious Disease Division

Abstract:

We compared primary Epstein-Barr virus (EBV) infection and suppression between Kenyan HIV-infected infants starting nevirapine- versus lopinavir/ritonavir-based antiretroviral regimens. Although the rate of EBV infection was similar between groups, infants receiving lopinavir/ritonavir suppressed EBV more rapidly. Our findings suggest specific antiretrovirals may potentially impact the risk of future EBV-associated malignancies.