Abnormalities of the alphabeta T-cell receptor repertoire in advanced myelodysplastic syndrome.

Publication Type:

Journal Article

Authors:

Campregher, Paulo V; Srivastava, Santosh K; Deeg, H Joachim; Robins, Harlan S; Warren, Edus H

Source:

Experimental hematology, Volume 38, Issue 3, p.202-12 (2010)

Keywords:

2010, Adolescent, Adult, Aged, Aged, 80 and over, Algorithms, Bone Marrow Cells, Center-Authored Paper, Clinical Research Division, Cluster Analysis, Complementarity Determining Regions, Female, Humans, Leukocytes, Mononuclear, Male, Middle Aged, Myelodysplastic Syndromes, Public Health Sciences Division, Receptors, Antigen, T-Cell, alpha-beta, Research Trials Office Core Facility - Biostatistics Service, Reverse Transcriptase Polymerase Chain Reaction, Shared Resources, Young Adult

Abstract:

Analysis of the alphabeta T-cell receptor (TCR) repertoire in patients with myelodysplastic syndrome (MDS) using the technique of TCR beta-chain spectratyping has provided valuable insight into the pathophysiology of cytopenias in a subset of patients with this heterogeneous disorder. TCR beta-chain spectratypes are complex data sets, however, and statistical tools for their comprehensive analysis are limited. The objective of the present work was to develop a method to enable quantitative evaluation and global comparison of spectratype data from different individuals and to study the prevalence of TCR beta repertoire abnormalities in MDS patients.