Abnormal timing of menarche in survivors of central nervous system tumors: A report from the Childhood Cancer Survivor Study.

Publication Type:

Journal Article


Cancer, Volume 115, Issue 11, p.2562-70 (2009)


2009, Adult, Age Factors, Case-Control Studies, Center-Authored Paper, Central Nervous System Neoplasms, Child, Child, Preschool, Dose-Response Relationship, Radiation, Female, Humans, Menarche, Outcome Assessment (Health Care), Public Health Sciences Division, Questionnaires, Radiation Dosage, Research Trials Office Core Facility - Biostatistics Service, RISK, Shared Resources, Siblings, Survivors


Children who receive high-dose radiotherapy to the hypothalamic-pituitary (H-P) axis may be at risk for both early and late puberty. To the authors' knowledge, data regarding the risk of altered timing of menarche after higher dose radiotherapy (RT), as used in the treatment of central nervous system (CNS) tumors, are limited.