[-2]proenzyme prostate specific antigen for prostate cancer detection: a national cancer institute early detection research network validation study.

Publication Type:

Journal Article


The Journal of urology, Volume 180, Issue 2, p.539-43; discussion 543 (2008)


2008, ADENOCARCINOMA, Aged, Aged, 80 and over, Area Under Curve, Early Diagnosis, Enzyme Precursors, Humans, Male, Middle Aged, National Cancer Institute (U.S.), Neoplasm Staging, Prognosis, Prostate-Specific Antigen, Prostatic Neoplasms, Public Health Sciences Division, Regression Analysis, ROC Curve, Sensitivity and Specificity, Tumor Markers, Biological, United States


This study evaluated the [-2]proenzyme prostate specific antigen serum marker using a blinded reference specimen set from 3 National Cancer Institute Early Detection Research Network centers from men with an indication for prostate biopsy.