Cameron Turtle

Appointments and Affiliations

 
 
University of Washington
Department of Medicine
Assistant Professor, Appointed: 2012
 
Fred Hutchinson Cancer Research Center
Clinical Research Division
Associate Member, Appointed: 2016
 
Seattle Cancer Care Alliance
Attending Physician
Professional Headshot of Cameron Turtle

Mailing Address

P.O. Box 19024
D3-100
1100 Fairview Avenue N

Seattle, Washington 98109-1024

United States

Contact

Phone: (206) 667-7073
Fax: (206) 667-7983

cturtle@fredhutch.org

Degrees

Ph.D., University of Queensland, Australia, 2005.
M.B.B.S. (Medicine), University of Sydney, Australia, 1993.

Research Interests

Dr. Turtle’s laboratory in the FHCRC Clinical Research Division, Program in Immunology is focused on understanding the characteristics of distinct subsets of human T cell, their potential utility for tumor immunotherapy and their role in immune reconstitution after hematopoietic stem cell transplantation (HCT).

Ongoing research projects include:

  1. Therapy of patients with B cell malignancies using CD19-specific chimeric antigen receptor (CAR)-modified T cells: We are conducting a large clinical trial investigating the use of CD19 CAR-T cells in patients with acute lymphoblastic leukemia, non-Hodgkin lymphoma and chronic lymphocytic leukemia. We manufacture and treat patients with CAR-T cells of defined subset composition, allowing us to administer a consistent product to each patient, which facilitates analyses of the relationships between infused product and clinical outcomes. We are conducting investigations into the mechanisms of failure of CAR-T cell therapy using phenotyping, transcriptional profiling, next generation sequencing and functional studies. We have new trials in development that address some of the mechanisms of immune escape in these patients.
  2. CAR-T cell therapy for acute myeloid leukemia (AML): AML may be more difficult to treat with CAR-T cells than B cell malignancies because of the lack of truly myeloid lineage-specific target antigens. We are developing new approaches to target AML using CAR-T cells.
  3. Perturbed immune reconstitution after allogeneic HCT is an important factor that contributes to many post-HCT complications. We are studying the roles of subsets of non-conventional T cells, such as mucosal-associated invariant T cells (MAIT cells), Treg cells, iNKT cells and Th17 cells in post-HCT immune reconstitution and development of post-HCT complications. With collaborators in the Fredricks Lab at FHCRC, we have a particular interest in investigating the role of the gastrointestinal microbiota in driving reconstitution of these subsets after HCT.

Memberships

American Society of Gene and Cell Therapy
American Society of Hematology
Royal Australasian College of Physicians
Royal College of Pathologists of Australasia

Honors and Awards

Fellow of the Royal Australasian College of Physicians
Fellow of the Royal College of Pathologists of Australasia

Previous Positions

2010-2011, Associate in Clinical Research, Fred Hutchinson Cancer Research Center
2008-2010, Research Associate, Fred Hutchinson Cancer Research Center
2005-2008, Postdoctoral Research Fellow, Fred Hutchinson Cancer Research Center
2004-2005, Attending Physician in Hemato-oncology, Westmead Hospital (Sydney, Australia)
2004, Attending Physician in Hemato-oncology, Mater Adult Hospital (Brisbane, Australia)
2001-2004, PhD Scholar, The University of Queensland, Mater Medical Research Institute (Brisbane, Australia)
2000, Fellow in Hemato-oncology/Pathology, Royal Prince Alfred Hospital (Sydney, Australia)
1997-2000, Fellow in Hemato-oncology/Pathology, Royal North Shore Hospital (Sydney, Australia)
1995-1996, Medical Physician in Training, Royal North Shore Hospital (Sydney, Australia)
1994, Resident, Royal North Shore Hospital (Sydney, Australia))
1993, Intern, Royal North Shore Hospital (Sydney, Australia)

Recent Publications

2018
2017
2016
2015
2014
2013
2012
2011
2010

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