Mohamed Sorror

Appointments and Affiliations

 
 
Fred Hutchinson Cancer Research Center
Clinical Research Division
Transplantation Biology
Assistant Member
University of Washington
School of Medicine
Medicine
Medical Oncology
Assistant Professor
Professional Headshot of Mohamed  Sorror

Mailing Address

1100 Fairview Ave. N
D1-100
Seattle, Washington 98109
United States

Contact

Phone: (206) 667-2765
Fax: (206) 667-6124
msorror@fhcrc.org

Degrees

M.Sc., Assiut University, Internal Medicine, 1998.
M.D., Assiut University, Faculty of Medicine, 1993.

Research Interests

My research is focused on studying the impacts of medical comorbidities on outcomes of hematopoietic cell transplantation (HCT) for hematologic malignancies in order to improve decision-making and lessen the HCT morbidity and mortality.

A new HCT-specific comorbidity index (HCT-CI) was developed to capture comorbidities at time of HCT and to predict outcomes. Current research is focused on validating the discriminative capacity of this index among patients transplanted at different institutions. The index is being modified by adding biomarkers and objective laboratory data to further improve its prognostic value.

The index is also used to investigate the biologic link between pretransplant comorbidities and post-transplant toxicities, graft-versus-host disease, causes of death, and quality of life. Other research efforts include evaluating the impact of comorbidities on rate of referral of acute myeloid leukemia patients to HCT, investigating molecular mechanisms that explain the association between comorbidities and HCT morbidity, and assessing the role of iron overload in HCT.

My research also involves new methods to maximize the benefits of nonmyeloablative conditioning and allogeneic HCT for older and medically infirm patients diagnosed with chronic lymphocytic leukemia or lymphoma. One approach is investigating whether the addition of anti-CD20 monoclonal antibody (rituximab) to the nonmyeloablative conditioning could improve survival. Another approach is combining high-dose myeloablative autologous HCT, for disease debulking, with allogeneic HCT from HLA-haploidentical donor using nonmyeloablative regimen, for continued graft-versus disease consolidation.

Languages

(Reading, Writing, Speaking)

Arabic: (Fluent, Fluent, Fluent)
English: (Fluent, Fluent, Fluent)

Memberships

American Society of Bone Marrow Transplantation
American Society of Clinical Oncology
American Society of Hematology

Honors and Awards

2005-2005, Merit Award, American Society of Clinical Oncology
2004-2004, Abstract Award, American Society of Bone Marrow Transplantation, Tandem BMT Annual Meeting
2003-2003, Abstract Award, American Society of Hematology, 45th Annual meeting

 

Recent Publications

2017
2016
Graf SA, Vaughn JE, Chauncey TR, Storer BE, Gopal AK, Holmberg LA, McCune JS, Bensinger WI, Maloney DG, Press OW et al..  2016.  Comorbidities, Alcohol Use Disorder, and Age Predict Outcomes after Autologous Hematopoietic Cell Transplantation for Lymphoma.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 22(9):1582-1587. Abstract
2015
Au BKC, Gooley TA, Armand P, Fang M, Madtes DK, Sorror ML, Boeckh MJ, Gibson CJ, Deeg HJ, Storb R et al..  2015.  Reevaluation of the pretransplant assessment of mortality score after allogeneic hematopoietic transplantation.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 21(5):848-54. Abstract
2014
Ringdén O, Brazauskas R, Wang Z, Ahmed I, Atsuta Y, Buchbinder D, Burns LJ, Cahn J-Y, Duncan C, Hale GA et al..  2014.  Second solid cancers after allogeneic hematopoietic cell transplantation using reduced intensity conditioning.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. Abstract
Li X, Brazauskas R, Wang Z, Al-Seraihy A, Baker KS, Cahn J-Y, Frangoul HA, Gajewski JL, Hale GA, Hsu JW et al..  2014.  Avascular Necrosis of Bone after Allogeneic Hematopoietic Cell Transplantation in Children and Adolescents.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. Abstract

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