Benoit Masse

Appointments and Affiliations

Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Associate Member, Appointed: 2003
University of Washington
School of Public Health and Community Medicine
Affiliate Associate Professor, Appointed: 2003
Professional Headshot of Benoit Masse

Mailing Address

1100 Fairview Ave. N. LE-400
P.O. Box 19024
Seattle, Washington 98109-1024
United States


Phone: (206) 667-6776
Fax: (206) 667-6888


Ph.D., University of North Carolina at Chapel Hill, Biostatistics, Epidemiology, 1993.
M.S., University of Montreal, Statistics, 1988.
B.S., University of Montreal, Mathematics, 1985.

Research Interests

My main statistical methods research interests are: (1) developing methods for analysis of infectious diseases data, (2) developing between-host mathematical models of infectious disease transmission and (3) validation of trial designs using between-host mathematical models. The majority of my recent collaborative work has been in HIV prevention trials and cohort studies. I am involved as lead statistician on a variety of trials of microbicides as preventive vaginal gel agents for sexual transmission of HIV and the use of ART as a preventive agent for the transmission of HIV in serodiscordant couples. In this role, I collaborate extensively on protocol teams and provide expertise in study design and other aspects of study development, conduct, and analysis. In addition, I currently manage fourteen (14) Statistical Research Associates and part of the statistical activities at the Statistical Center for HIV/AIDS Research and Prevention (SCHARP) within the Public Health Division.


Reading, Writing, Speaking

English: Fluent, Fluent, Fluent
French: Fluent, Fluent, Fluent


Clinical Trials Grants Committee of the Canadian Institutes of Health Research
HIV Prevention Trials Network

Honors and Awards

2004, Cohort OMEGA Research Team nomination, CIHR Knowledge Translation Award
1993, Delta Omega Society travel award,
1993, UNC Graduate School travel award,
1993, Inducted in the Delta Omega Society, The Honorary Public Health Society,
1992, Dissertation Fellowship from UNC-Chapel Hill Graduate School,
1992, Travel award from the Department of Biostatistics, UNC-Chapel Hill,
Scholarship for the PhD program from the Quebec Health Research Funds, Canada,
Special commendation from the Department of Biostatistics of the University of North Carolina at Chapel Hill for the theoretical part of the Doctoral examination,

Previous Positions

2000-2003, Assistant Member, Fred Hutchinson Cancer Research Center, Biostatistics
2000-2004, SRAs Manager, Fred Hutchinson Cancer Research Center, Statistical Center for HIV/AIDS Research and Prevention
2000-2002, Associate Professor, Laval University, School of Medicine, Social and Preventive Medicine
1998-2000, Director, Service of Methodological Support for Clinical Research Center, Laval University Affiliated Research Hospital
1993-2002, Adjunct Professor, Laval University, Mathematics and Statistics
1993-2000, Assistant Professor, Laval University, School of Medicine, Social and Preventative Medicine


  • MTN SDMC (Principal Investigator):: Leadership for HIV/AIDS Clinical Trials Networks; Statistical and Data Management Center for the Microbicide Trials Network, 2006 to 2013., 2006 to 2013.
  • CIHR (co-investigator): Efficacy of a non-pharmacologic treatment by hypnosis for pain associated with voluntary pregnancy interruption: a clinical trial, $189,627 CAN, 2004 to 2006.
  • CFAR (co-investigator): Multilevel Intervention Strategies for HIV Prevention: Mathematical Modeling for Efficacy Trials, 125,000 USD annual, 2004 to 2009.
  • Flax Council of Canada (co-investigator): Non-traditional markers of cardiovascular disease and crushed flaxseed versus placebo among menopausal women: a satelite study, $61,500 CAN, 2001 to 2002.
  • SSHRCC (co-investigator): Psychosocial work environment and mental health problems: a 8-year prospective study on 9,000 white collar workers, $208,016 CAN, 2001 to 2004.
  • HIV/AIDS FRSQ-Network (PI): Methodological and biostatistical support to the members of the network, $75,000 CAN / year, 2000 to 2002.
  • Flax Council of Canada (co-investigator): Flaxseed in menopaused women: a randomized clinical trial, $91,272 CAN, 2000 to 2003.
  • NCIC-CBCRI (co-investigator): Determinants of survival in node-negative breast cancer - a population based study, $251,717 CAN, 2000 to 2002.
  • NCIC (co-investigator): A multi-component intervention to prevent delirium in terminally ill cancer patients, $285,704 CAN, 2000 to 2003.
  • NCIC-CBCRI (co-investigator): Insulin-like growth factors and breast density, $548,831 CAN, 2000 to 2003.
  • FRSQ (co-investigator): Psyshosocial work environment and recurrence risk of a cardiac event in subjects returning to work after a first myocardial infraction, $118,575 CAN, 2000 to 2002.
  • NHDRP (co-PI): Development of a novel and improved HIV-1 vaccine efficacy measure, $46,672 CAN, 1999 to 2000.
  • NCIC-CBCRI (co-investigator): Family costs of breast cancer: Extent, determination and relation with QOL, $247,768 CAN, 1999 to 2001.
  • Quebec Heart Foundation (co-investigator): Work environment, coronary diseases, and blood pressure, $75,000 CAN, 1999 to 2000.
  • MRC (co-investigator): Clinical trial on the efficacy of flaxseed as a hormonal replacement therapy in menopaused women, $316,000 CAN, 1999 to 2002.
  • UNAIDS (Principal Investigator): Data management, analysis, and monitoring of the COL-1492 protocol: COL-1492 in the prevention of transmission of STD's and HIV, $343,050 USD, 1998 to 2002.
  • Quebec Heart Foundation(co-investigator): Return to work after myocardial infraction, $45,000 CAN, 1998 to 2001.
  • MRC (co-investigator): Psychosocial environment, coronary diseases, and blood pressure, $252,987 CAN, 1998 to 2001.
  • FRSQ (co-investigator): Psychosocial work environment and recurrence risk of a cardiac event in subjects returning to work after a first myocardial infraction, $117,989 (renewal), 1998 to 2000.
  • MRC (co-investigator): Timing of palliative hormonal therapy and prostate cancer survival: A population based study, $39,745 CAN, 1998 to 1999.
  • IRSST (consultant): Back to work prognostic for workers with back problems, $245,280 CAN, 1998 to 2001.
  • NCIC (co-investigator): Delirium in terminally ill cancer patients, $14,999 CAN, 1997 to 1998.
  • MRC (co-PI): Phase III HIV vaccine efficacy trials: efficacy measures, sample size, power and precision, $84,262 CAN, 1996 to 1998.
  • NHRDP (co-PI): Estimation of sexual networks for the study of HIV and other STD's, $60,000 CAN, 1996 to 1998.
  • Saint-Sacrement Hospital Foundation (co-investigator): Statistical methods for the determination of reference values in neurophysiology, $6,000 CAN, 1996 to 1997.
  • Quebec Cancer Foundation (co-investigator): Work problems after breast cancer; a population based, comparative study, $25,000 CAN, 1996 to 1997.
  • FRSQ (co-investigator): Clinical trial on norfloxacine: anitbacterial therapy in urinary infection for old subjects, $119,778 CAN, 1996 to 1998.
  • NHRDP and MRC (co-investigator): Study of the incidence and psyscosocial determinants of HIV infection among homosexual and bisexual men in Montreal: The Omega Cohort, $3,222,280 CAN, 1996 to 2003.
  • NCIC-CBCRI (co-investigator): Quality of life among spouses of breast cancer patients, $340,690 CAN, 1995 to 1998.
  • FRSQ (co-investigator): Psychosocial work environment and recurrence risk of a cardiac event in subjects returning to work after a first myocardial infraction, $118,114 CAN, 1995 to 1997.
  • CQRS (co-investigator): Evaluation of an intervention program on the sexuality and the prevention of STD and AIDS for young mothers in rehabilitation centers, $151,142 CAN, 1995 to 1997.
  • FRSQ (co-investigator): Team grant, Epidemiology Reseach Group, Laval University, $300,000 CAN / year, 1994 to 2001.
  • National Cancer Institute of Canada (NCIC): Clinical Trial: Beta-carotene and alpatocopherol chemoprevention of second primary malignancies in head and neck cancer patients, $629,952 CAN, 1994 to 1997.
  • NHRDP (co-investigator): Effect of biomechanical and work environment factors on risk of early delivery and abnormal pregnancy, $258,514 CAN, 1994 to 1999.
  • National Cancer Institute of Canada (NCIC): Terry Fox Award Research Scholar, $125,004 CAN, 1993 to 1996.
  • National Cancer Institute of Canada (NCIC): Operating Funds, $32,000 CAN, 1993 to 1994.


Recent Publications

Lauzier S, Levesque P, Drolet M, Coyle D, Brisson J, Masse B, Robidoux A, Robert J, Maunsell E.  2011.  Out-of-Pocket Costs for Accessing Adjuvant Radiotherapy Among Canadian Women With Breast Cancer.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 29(30):4007-13. Abstract

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