Sarah Holte

Appointments and Affiliations

Principal Staff Scientist
Public Health Sciences Division
Biostatistics and Biomathematics Program
Principal Staff Scientist, Appointed 2007
University of Washington
Department of Biostatistics
Department of Global Health
Affiliate Associate Professor, Appointed 2004
Professional Headshot of Sarah Holte

Mailing Address

Fred Hutchinson Cancer Research Center
P.O. Box 19024
Seattle, Washington 98109-1024
United States


Phone: (206) 667-6975
Fax: (206) 667-7004


Ph.D., University of Oregon, Mathematics, 1990.
M.A., University of Oregon, Mathematics, 1987.
B.A., University of Minnesota, Mathematics, 1984.

Research Interests

Using differential and difference equations to model the biology of HIV and the immune system.

Previous Positions

2001-2007: Senior Staff Scientist, Fred Hutchinson Cancer Research Center.
2003-2004: Research Associate Professor, Mathematics, North Carolina State University.
1995-2001: Staff Scientist, Fred Hutchinson Cancer Research Center.
1995: Statistical Research Associate, Fred Hutchinson Cancer Research Center.
1993-1995: Postdoctoral Fellow, Department of Biostatistics, University of Washington.
1990-1995 (on leave 9/93-6/95): Assistant Professor, Department of Mathematics, University of Missouri-Rolla.

Additional Experience

2008-present: Director of Fred Hutchinson Center Public Health Sciences Biostatistics Shared Resource.
1999-present: Director of Biostatistics Core for Seattle Primary Infection Program (SeaPIP).
1999-2003: Director of Statistical Center for Acute/Early HIV Infection Network (AIEDRP).


  • NIH/NIAID P30 AI-27757: Center for AIDS Research, University of Washington, Director, Biometrics Core, Co-Investigator (PI King Holmes, MD. PhD, University of Washington).
  • NIH/NIAID P01 AI-057005: Immunological and Virological Events in Early HIV Infection, Director, Biostatistics Core, Co-Investigator (PI James Mullin, PhD).
  • NIH R01 AI055343: Mathematical and Experimental Models for HIV Dynamics, Principal Investigator, April 2003 – December 2009.
  • NIH R01 GM67299: Modeling, Estimation and Control in HIV Dynamics, Co-Investigator (Principal Investigator H.T. Banks, North Carolina State University), July 2002 - December 2004.
  • Missouri Research Board: Modeling Dynamical Systems With Inverse Limits, Principal Investigator, June 1993- August 1994.
  • Oak Ridge Associated Universities Junior Faculty Enhancement Award, Principal Investigator, June 1992-August 1993.

Recent Publications

Kuzma JN, Hagman DK, Cromer G, Breymeyer KL, Roth CL, Foster-Schubert KE, Holte SE, Weigle DS, Kratz M.  2018.  Intra-individual variation in markers of intestinal permeability and adipose tissue inflammation in healthy normal weight to obese adults.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. Abstract
Thompson B, Vilchis H, Moran C, Copeland W, Holte S, Duggan C.  2014.  Increasing cervical cancer screening in the United States-Mexico border region.. The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association. 30(2):196-205. Abstract
Coronado GD, Holte SE, Vigoren EM, Griffith WC, Barr DB, Faustman EM, Thompson B.  2012.  Do Workplace and Home Protective Practices Protect Farm Workers? Findings From the "For Healthy Kids" Study. Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine. 54(9):1163-1169. Abstract
Gwamaka M, Kurtis JD, Sorensen BE, Holte S, Morrison R, Mutabingwa TK, Fried M, Duffy PE.  2012.  Iron Deficiency Protects Against Severe Plasmodium falciparum Malaria and Death in Young Children.. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 54(8):1137-44. Abstract

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