Steven Hahn

Appointments and Affiliations

Fred Hutchinson Cancer Research Center
Basic Sciences Division
Member, Appointed: 1988
Professional Headshot of Steven  Hahn

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Ave. N.
Mailstop A1-162
P.O. Box 19024
Seattle, Washington 98109-1024
United States


Phone: (206) 667-5261
Fax: (206) 667-6497


Ph.D., Brandeis University, Biochemistry, 1984.
B.A., University of California, Santa Barbara, Biochemistry, 1979.

Research Interests

The research focus of the Hahn Laboratory is the mechanism and regulation of transcription. In eukaryotes, RNA polymerases are components of large protein machines that integrate regulatory signals and position polymerase at gene regulatory regions. Most subunits of the transcription machinery are essential for viability, and regulation of transcription is one of the key steps controlling cell identity, growth, development and stress response. Misregulation of transcription is a major cause of human disease. Research in the laboratory aims to decipher key mechanisms used by the transcription machinery and by regulatory factors that are fundamental to the regulation of transcription. Nearly all of these mechanisms have been conserved in eukaryotes. The laboratory provides an excellent learning environment for students and postdoctoral fellows to address scientific questions using a multidisciplinary approach.

Our long term goals are to understand: (i) the mechanism of the general transcription factors in promoting transcription by RNA polymerase and (ii) the mechanism of transcription activation by gene-specific regulatory factors.

Please see the Hahn Lab website for more information about our work.

Honors and Awards

1997-2005, Investigator, Howard Hughes Medical Institute
1993-1998, Scholar Award, Leukemia and Lymphoma Society
1990-1993, Junior Faculty Award, American Cancer Society (ACS)
1984-1987, Postdoctoral fellowship, Damon Runyon Walter Winchell Cancer Fund

Previous Positions

1997-2005, Investigator, Howard Hughes Medical Institute
1984-1988, Fellow, Massachusetts Institute of Technology, Dept of Biology, with L. Guarente


  • National Institutes of Health (NIH): Molecular Analysis of Eukaryotic Transcription, 2005 to 2013.
  • National Institutes of Health (NIH): Mechanisms of Eukaryotic Transcription Activation, 2005 to 2010.

Recent Publications


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