William M. Grady

Appointments and Affiliations

University of Washington Medical Center
School of Medicine
Section Chief, Appointed: 2007
Fred Hutchinson Cancer Research Center
Clinical Research Division
Member, Appointed: 2011
University of Washington Medical Center
School of Medicine
Professor, Appointed: 2011
Seattle Cancer Care Alliance
GI Cancer Prevention Program
Medical Director, Appointed: 2005
Professional Headshot of William M. Grady

Mailing Address

1100 Fairview Ave. N.
P.O. Box 19024
Mailstop D4-100
Seattle, Washington 98109
United States


Phone: (206) 667-1107
Fax: (206) 667-2917


M.D., University of Michigan - Ann Arbor, 1990.
B.S., University of Michigan - Ann Arbor, Biomedical Sciences, 1987.

Research Interests

Molecular and cell biology of gastrointestinal cancer: genetic and epigenetic alterations in cancer

Additional Experience

Clinical management of gastrointestinal cancer family syndromes
Colon cancer prevention
Barretts esophagus

Future Research

Biomarkers for colon cancer prevention
Biomarkers for optimizing management of Barretts esophagus


(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)


American Association for Cancer Research
American Association for the Study of Liver Disease
American College of Gastroenterology
American Gastroenterological Association

Honors and Awards

2009, Member, Society of Clinical Investigation
2008-2013, Burroughs Wellcome Clinical Scientist Award in Translational Research, Burroughs Wellcome Fund, Fred Hutchinson Cancer Research Center
2005-2010, Presidential Early Career Award for Scientists and Engineers (PECASE), Department of Veterans Affairs
2002-2005, Mallinckrodt Scholar Award, 42nd Scholar, Edward Mallinckrodt Jr. Foundation
2002-2007, Damon Runyon-Lilly Clinical Investigator Award, Damon Runyon Cancer Research Foundation
2001, John Walsh Memorial GIDH Award in Basic Research, John Walsh Memorial
1997, ADHF Advanced Research Training Award, ADHF
1993, Outstanding Senior Resident Award, University of Michigan
American Society of Clinical Investigation Member, American Society of Clinical Investigation

Previous Positions

2000-2004, Assistant Professor, Vanderbilt University, Gastroenterology
1999-1999, Assistant Professor, Case Western Reserve University, Gastroenterology
1998-1999, Instructor, Case Western Reserve University, Gastroenterology
1993-1994, Postdoctoral fellow, Fred Hutchinson Cancer Research Center, Laboratory of D. Hockenbery, M.D., Molecular Biology


Methods and compositions for detecting cancers associated with methylation of hMLH1 promoter DNA, Patent Number: 6858388 B2, 2005, Institution, United States.

Recent Publications

Cui J, Cai Y, Hu Y, Huang Z, Luo Y, Kaz AM, Yang Z, Chen D, Fan X, Grady WM et al..  2016.  Epigenetic silencing of TPM2 contributes to colorectal cancer progression upon RhoA activation.. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 37(9):12477-12483. Abstract
Sun X, Elston RC, Barnholtz-Sloan JS, Falk GW, Grady WM, Faulx A, Mittal SK, Canto M, Shaheen NJ, Wang JS et al..  2016.  Predicting Barrett's esophagus in Families: An Esophagus Translational Research Network (BETRNet) Model Fitting Clinical Data to a Familial Paradigm.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 25(5):727-735. Abstract

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