Theodore A. Gooley

Appointments and Affiliations

Fred Hutchinson Cancer Research Center
Clinical Statistics
Clinical Research
Member, Appointed: 2005
University of Washington
School of Public Health and Community Medicine
Affiliate Professor, Appointed: 2006
Fred Hutchinson Cancer Research Center
Public Health Sciences
Member (Joint Appointment), Appointed: 2005
Professional Headshot of Ted A. Gooley

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Avenue N., D5-360
P.O. Box 19024
Seattle, Washington 98109-1024
United States


Phone: (206) 667-6533
Fax: (206) 667-6358


Ph.D., University of Arizona, Applied Mathematics, 1990.
B.S., Washington State University, Mathematics, 1984.

Research Interests

Clinical trials and methods of data analysis in stem cell transplantation.

The Clinical Research Division at the FHCRC performs more stem cell transplants than any other institution in the world. The first transplant in Seattle was done in 1969, and currently roughly 450 transplants are done yearly. These facts put the FHCRC in a unique position to conduct both small- and large-scale clinical trials designed to address some of the most important and interesting questions that face the transplantation community today. The large volume of data generated from past transplants also provides a rich database from which information can be used to generate hypotheses and to monitor progress made in the field.

In recent years, many dose-finding studies have been designed within the Clinical Division with the goal of determining whether of not an effective dose of a treatment can be found such that the dose appears both safe and efficacious. This is in contrast to the more standard Phase I setting where one may be concerned only with safety and not efficacy. One such example is selective depletion of T cells in the donor marrow, where it is desired to find a dose of T cells that is associated with acceptable rates of graft failure while at the same timebeing associated with acceptable rates of severe graft-versus-host disease.

With the advent of the National Marrow Donor Program, use of alternative donors is becoming more commonplace for patients who lack a suitable family-member donor. It has beenshown in certain diseases that the time from diagnosis to transplant is an important prognostic factor in predicting outcome after transplantation and that outcome is adversely affected by donors who fail to share certain HLA antigens with the patient. A decision often needs to be made by both patient and physician whether to get transplanted early with a less-than-optimal donor or to wait longer in the hope of finding a more suitable donor. We are currently in the process of dealing with these and related issues for patients with chronic myeloid leukemia who receive a transplant from an unrelated donor.

The prevention and treatment of fungal and viral infections continues to be a problem following stem cell transplantation due to the immunocompromised condition of the patient. We have completed several randomized, controlled trials in recent years, and others are currently underway. These trials have led to significant progress in the prevention and treatment of certain infections, and the resultsof past and current clinical trials continue to shape strategies used to deal with such complications.


American Statistical Association
Society for American Baseball Research
Society for Clinical Trials

Honors and Awards

Phi Beta Kappa
Phi Kappa Phi

Previous Positions

2002-2006, Affiliate Associate Professor, University of Washington, School of Public Health and Community Medicine, Biostatistics
1999-2005, Associate Member, Fred Hutchinson Cancer Research Center, Clinical Research Division, Clinical Statistics
1999-2005, Associate Member (Joint Appointment), Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Biostatistics
1993-2002, Affiliate Assistant Professor, University of Washington, School of Public Health and Community Medicine, Biostatistics
1992-1999, Assistant Member, Fred Hutchinson Cancer Research Center, Clinical Statistics, Clinical Research Division
1992-1999, Assistant Member (Joint Appointment), Fred Hutchinson Cancer Research Center, Public Health Sciences Division
1991-1992, Post-Doctoral Fellow, University of Rochester, Statistics
1984-1986, Graduate Teaching Assistant, University of Arizona, Mathematics
1983-1984, Undergraduate Teaching Assistant, Washington State University, College of Sciences, Mathematics

Recent Publications

Yarchoan M, Dougan ML, Tjota MY, Milliner BHA, Adler BL, Armah KA, Gooley TA, Close KL, Close J, Hirsch IB.  2011.  Who will manage American patients with diabetes? Residents' career preferences and perceptions of diabetes care. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 17(2):235-9. Abstract
Lord JD, Hackman RC, Gooley TA, Wood BL, Moklebust AC, Hockenbery DM, Steinbach G, Ziegler SF, McDonald GB.  2011.  Blood and gastric FOXP3+ T cells are not decreased in human gastric graft-versus-host disease.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 17(4):486-96. Abstract

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