Jarrod A. Dudakov

Appointments and Affiliations

 
 
Fred Hutchinson Cancer Research Center
Clinical Research Division
Program in Immunology
Assistant Member, Appointed: 2016
Professional Headshot of Jarrod A. Dudakov

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Ave. N.
P.O. Box 19024
D3-100
Seattle, Washington 98109-1024

Contact

Phone: (206) 667-3204
Fax: (206) 667-7983
jdudakov@fredhutch.org

Degrees

2009 PhD, Immunology & Stem Cell Biology, Monash University (Melbourne, Australia)
2003 BS (with honors), Immunology, Monash University (Melbourne, Australia)
2002 BS, Immunology & Biochemistry, Monash University (Melbourne, Australia)
2002 BA, Politics, Monash University (Melbourne, Australia)

Research Interests

T cell development in the thymus, or thymopoiesis, is a complex process that results in the generation of naïve T cells with a diverse receptor repertoire. This process is critically dependent on the close interaction between thymocytes and the supporting stromal cell network; which is comprised of hematopoietic cells such as macrophages and dendritic cells, and non-hematopoietic cells such as fibroblasts, endothelial cells (ECs) and highly specialized thymic epithelial cells (TECs). These interactions not only promote the generation of a pool of T cells with reactivity to an astonishingly distinct array of epitopes, but also ensure that these T cells do not react against self. Using the thymus as a model for tissue damage and endogenous regeneration, the Dudakov laboratory studies the damage response pathways that leads to restoration of immune function after damage such as that caused by age, stress, infection and common cancer treatments like cytoreductive chemo- and radiation-therapy.

Ongoing projects include:

  1. The role of innate lymphoid cells and interleukin-22 in mediating thymic repair
  2. The damage-sensing triggers that lead to tissue regeneration
  3. The interaction between different regenerative networks in the thymus
  4. The generation of novel therapeutic strategies to boost immunity by stimulating thymic function

Memberships

American Association of Immunologists (AAI)
American Society of Hematology (ASH)
International Society for Stem Cell Research (ISSCR)

Honors and Awards

2015 Mechtild Harf Award; DKMS Foundation for Giving Life
2013 K99/R00 Pathway to Independence Award; NIH-NCI
2013 Memorial Sloan Kettering Cancer Center (MSKCC) Postdoctoral Research Award
2013 Scholar Award; American Society for Hematology (ASH)
2011 CJ Martin Overseas Biomedical Research Fellowship; Australian National Health and Medical Research Council (NHMRC)
2010 Post-doctoral Research Fellowship; Leukemia and Lymphoma Society (USA)
2009 Sydney Parker Smith Research Fellowship; Cancer Council of Victoria (Australia)

Previous Positions

2013-2016 Senior Research Scientist, Immunology, Memorial Sloan-Kettering Cancer Center (MSKCC)
2010-2013 Post-Doctoral, Immunology, Memorial Sloan Kettering Cancer Center (MSKCC)
2009-2010 Post-Doctoral, Immunology & Stem Cell Biology, Monash University (Melbourne, Australia)

Recent Publications

2018
2017
2016

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