Gregory J. Brennan

Appointments and Affiliations

 
 
Fred Hutchinson Cancer Research Center
Human Biology
Research Associate
 

Mailing Address

Fred Hutchinson Cancer Research Center
C2-023
P.O. Box 19024

Seattle, Washington 98109-1024
United States

Contact

Phone: (206) 667-5199
Fax: (206) 667-6523

gbrennan@fredhutch.org

Degrees

Ph.D., University of Washington, Microbiology, 2008.
D.V.M., Colorado State University, 2003.
B.S., Microbiology, Colorado State University, 2000.

Research Interests

My central hypothesis is that dsRNA binding and direct interactions between RhCMV TRS1 and AGM PKR are required for TRS1-mediated inhibition of PKR, and that African green monkey PKR genotypes that are resistant to RhCMV TRS1-mediated inhibition have evolved amino acid changes that disrupt these interactions. This multi-disciplinary study will 1) identify the functional domains that govern RhCMV TRS1 species-specific activity, and 2) determine the functional consequences of allelic variation in African green monkey PKR.

Honors and Awards

2010 International Herpesvirus Workshop Phase II Travel Award, 2010
26th Annual Nonhuman Primate Models for AIDS Symposium Young Investigator, 2008
Neal B. Groman Award for Excellence in Teaching, 2005
University of Washington Top Scholar Award, 2003
Roberta Hartman Memorial Scholarship recipient, 2001, 2002
CVMBS Professional Veterinary Medicine Scholarship, 2000
Merck Veterinary Scholar’s Program, 2000

Previous Positions

2008-2009: Research Associate, University of Washington, Department of Microbiology
2003-2008: Graduate Student, University of Washington, Department of Microbiology
2000-2003: Research Assistant, Colorado State University, Department of Microbiology, Immunology, and Pathology
2000: Research Assistant, Colorado State University, Veterinary Diagnostic Laboratory
1999: Research Assistant, Colorado State University, Department of Microbiology

Funding

  • American Cancer Society (PF-12-017-01-MPC): Inhibition of the interferon-induced PKR by RhCMV TRS1, $102,000, January 2012 to December 2013
  • National Institutes of Health (K08 AI067138): Determinants of host adaptation in a Macaca nemestrina-adapted HIV-2 isolate, $237,807, March 2006 to January 2011

 

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