Comparative Pathology

Saturday 08/01/2009

Have you met our Comparative Pathologist? 

Dr. Sue Knoblaugh is a board certified veterinary pathologist with expertise in comparative pathology and training in laboratory animal pathology with an emphasis on mouse pathology.   She has worked with several genetically engineered mouse models of human disease.  Pathology services include: hands on mouse necropsy instruction, consultation and evaluation of histopathology slides, description and interpretation of gross and microscopic lesions, assistance or collaboration in manuscript and grant preparation (lesion description, data summary and interpretation, image production).  

She works closely with Experimental Histopathology to provide consultation on experimental design, sample collection, fixation, stains, immunohistochemistry, and to develop specific mouse tissue protocols for individual labs.  She also works closely with the Animal Health shared resource providing necropsy and pathology support.   

She loves teaching and encourages graduate students and post-docs to learn pathology.  Her door is always open for reviewing slides and helping with research projects.  For further details, please contact Sue at 206-667-6971 or sknoblau@fhcrc.org.

Why do I need a veterinary pathologist?  If you use animal models for your research, please read the following:

Over 60% of National Institutes of Health (NIH) extramural funding involves animal-related research. Mice represent approximately 80-90% of the animals used in biomedical research, yet mice are often the least understood laboratory animal species. The number of genetically engineered mouse (GEM) mutants has risen substantially and the use of GEM models for hypothesis-driven research has also increased. All investigators using mice for biomedical research should collaborate with a pathologist with appropriate mouse expertise to provide the interpretation of lesions in their mice. A veterinary pathologist will help ensure that normal organs are not misidentified and that tumors and related biological processes are not misinterpreted.  For further reading, please see the following references:

1.    http://www.nature.com/labinvest/journal/v88/n1/full/3700695a.html#bib46#bib46
2.    Ward JM, Sundberg J. Preventing publication errors: the need for a pathologist in the evaluation of genetically engineered mice. Vet Pathol Suppl 2004;41:562.

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Shared Resources are core facilities that provide services and access to specialized equipment for research activities.


Rajesh K. Uthamanthil, DVM, PhD, DACLAM

Associate Vice President, Shared Resources