Polycomb-mediated repression during terminal differentiation: what don't you want to be when you grow up?

Publication Type:

Journal Article


Genes & development, Volume 25, Issue 10, p.997-1003 (2011)


2011, Animals, Basic Sciences Division, Cell Differentiation, Center-Authored Paper, Clinical Research Division, DROSOPHILA, Gene Expression Regulation, Developmental, Human Biology Division, Humans, MICE, Muscle Development, Muscle, Skeletal, Public Health Sciences Division, Repressor Proteins, Stem Cells, TRANSCRIPTION FACTORS


Chromatin-modifying enzymes are known to be critical components for the correct differentiation of embryonic stem cells into specific lineages, such as neurons. Recently, the role of Polycomb group proteins has been studied in the specification and differentiation of muscle stem cells. In this perspective, we review a recent study by Juan and colleagues (pp. 789-794) in Genes & Development of the role of the polycomb group protein Ezh2 in muscle stem cells, and discuss the implications for general lineage restriction.