Genetic variation in DNA repair genes and prostate cancer risk: results from a population-based study.

Publication Type:

Journal Article

Source:

Cancer causes & control : CCC, Volume 21, Issue 2, p.289-300 (2010)

Keywords:

2010, Adult, African Americans, Aged, BRCA2 Protein, Center-Authored Paper, Chi-Square Distribution, DNA repair, European Continental Ancestry Group, Gene Frequency, Genetic Predisposition to Disease, Genetic Variation, Genotype, Humans, LINKAGE DISEQUILIBRIUM, Male, Middle Aged, Polymorphism, Single Nucleotide, Population Surveillance, Prostatic Neoplasms, Public Health Sciences Division, Risk Factors, Shared Resources, Specimen Processing Core Facility, Xeroderma Pigmentosum Group D Protein

Abstract:

DNA repair pathways are crucial to prevent accumulation of DNA damage and maintain genomic stability. Alterations of this pathway have been reported in many cancers. An increase in oxidative DNA damage or decrease in DNA repair capacity with aging or due to germline genetic variation may affect prostate cancer risk.