Evaluation of a variant in the transcription factor 7-like 2 (TCF7L2) gene and prostate cancer risk in a population-based study.

Publication Type:

Journal Article

Source:

The Prostate, Volume 68, Issue 7, p.740-7 (2008)

Keywords:

2008, Aged, Case-Control Studies, Center-Authored Paper, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Prostate-Specific Antigen, Prostatic Neoplasms, Public Health Sciences Division, Risk Factors, Shared Resources, Specimen Processing Core Facility, T Cell Transcription Factor 1, Washington

Abstract:

Transcription factor 7-like 2 (TCF7L2) is a high mobility group-box containing protein that is a critical member of the Wnt/beta-catenin canonical signaling pathway. In addition to its recently recognized role in diabetes, aberrant TCF7L2 expression has been implicated in cancer through regulation of cell proliferation and apoptosis by c-MYC and cyclin D. It has been hypothesized that germline variants within the TCF7L2 gene previously associated with diabetes may affect cancer risk through the Wnt/beta-catenin signaling pathway. Specifically, the same risk allele of single nucleotide polymorphism (SNP) rs12255372 that is associated with diabetes (T allele) has recently been associated with an increased risk of breast cancer.