Dynamic changes in fetal microchimerism in maternal peripheral blood mononuclear cells, CD4+ and CD8+ cells in normal pregnancy.

Publication Type:

Journal Article

Source:

Placenta, Volume 31, Issue 7, p.589-94 (2010)

Keywords:

2010, Adult, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Center-Authored Paper, Chimerism, Clinical Research Division, Female, Fetus, Flow Cytometry Core Facility, Gestational Age, HLA Antigens, Humans, Leukocytes, Mononuclear, Maternal-Fetal Exchange, PREGNANCY, Pregnancy Trimester, Third, Prospective Studies, Research Trials Office Core Facility - Biostatistics Service, Shared Resources

Abstract:

Cell trafficking during pregnancy results in persistence of small populations of fetal cells in the mother, known as fetal microchimerism (FMc). Changes in cell-free fetal DNA during gestation have been well described, however, less is known about dynamic changes in fetal immune cells in maternal blood. We have investigated FMc in maternal peripheral blood mononuclear cells (PBMC) longitudinally across gestation.