Cytoskeleton responses in wound repair.
Publication Type:Journal Article
Source:Cellular and molecular life sciences : CMLS, Volume 69, Issue 15, p.2469-2483 (2012)
Keywords:2012, Basic Sciences Division, Center-Authored Paper, Mar 2012, March 2012, Scientific Imaging Core Facility, Shared Resources
Wound repair on the cellular and multicellular levels is essential to the survival of complex organisms. In order to avoid further damage, prevent infection, and restore normal function, cells and tissues must rapidly seal and remodel the wounded area. The cytoskeleton is an important component of wound repair in that it is needed for actomyosin contraction, recruitment of repair machineries, and cell migration. Recent use of model systems and high-resolution microscopy has provided new insight into molecular aspects of the cytoskeletal response during wound repair. Here we discuss the role of the cytoskeleton in single-cell, embryonic, and adult repair, as well as the striking resemblance of these processes to normal developmental events and many diseases.
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