Karen L. Syrjala
Postdoctoral Fellowship, University of Washington and Fred Hutchinson Cancer Research Center, Pain/Behavioral Medicine, 1985.
Ph.D., Boston University, Clinical Psychology, 1983.
M.A., Boston University, Clinical Psychology, 1980.
B.A., Wellesley College, Psychology and English, 1973.
My research has focused on defining long term and late complications of hematopoietic stem cell transplantation, clinical trials to improve outcomes during and after cancer treatment, cancer pain and symptom management, and opioid side effects. As we know, cancer not only attacks organ systems, but also influences neuroendocrine function, neurocognitive function and, directly or indirectly, affects emotions, thinking, behaviors, physical symptoms, family systems - in short the whole person. Our Biobehavioral Sciences research investigates methods of integrating behavioral and biological treatments, with goals of 1) optimizing patients' participation in their own care, 2) reducing symptoms and complications of treatment or the disease, and 3) improving long term outcomes.
At the Center, our research first designed and tested interventions to treat the most common symptoms during cancer treatment. Targeted symptoms included pain, stress and nausea/emesis. Methods included hypnosis, imagery and coping skills training combined with patient-controlled-analgesia. As our research progressed, we identified needs for cancer patients with pain to better understand their treatments, and needs for better scientific understanding of opioid side effects so that cancer patients could receive effective pain relief. Our longitudinal prospective studies out to 10 years have also identified problems in cancer survivors that require more actively integrated medical and behavioral treatments. These problems included long term fatigue, cognitive deficits, and hormone-related outcomes such as menopausal symptoms and sexual dysfunction. All of our intervention research is tested through randomized controlled clinical trials, with interdisciplinary collaborators. In a multi-site trial to enhance recovery after high dose treatment, we have tested interventions provided by telephone, along with print and video materials, to patients around the country. This is the second step in our trials to improve outcomes one to five years after treatment. Other trials examine Internet-based methods for improving communication and surveillance of complications for cancer patients and caregivers.
To achieve our goals of providing cost-effective and time-conserving methods for physicians, nurses, psychologists and other health care providers to treat cancer-related problems, we have developed videotapes and print materials for patients and family members. These materials educate patients and family members living with treatment effects (Relieving Cancer Pain, Focus Forward: Life after Transplant). Dr. Syrjala also has participated in developing guidelines for treating cancer pain including those by the American Pain Society and the National Comprehensive Cancer Network.
Measures have been needed that adequately assess symptoms so that we can effectively determine appropriate treatment and assess outcomes. We have developed a number of self-report tools for this purpose: Patient Cancer and Treatment Distress; Caregiver Cancer and Treatment Distress, Sexual Function Questionnaire, Family & Work Function, Somatic Side Effects of Opioids, Cognitive & Affective Side Effects of Opioids.
All of this biobehavioral research is interdisciplinary, integrating psychology and psychiatry investigators with our colleagues in pharmacology, anesthesiology, oncology, neurosciences, and rehabilitation medicine.
American Pain Society
American Psycho-social Oncology Society
American Psychological Association
International Association for the Study of Pain
Society of Behavioral Medicine
Post-Doctoral Fellowship, Pain & Behavioral Medicine, Anesthesiology, Multidisciplinary Pain Center, 1985
Provision of integrated psychosocial services for cancer survivors post-treatment.. The Lancet. Oncology. 18(1):e39-e50.. 2017.
National Institutes of Health Hematopoietic Cell Transplantation Late Effects Initiative: Consensus Recommendations for Patient-Centered Outcomes.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.. 2016.
Trajectories of Quality of Life after Hematopoietic Cell Transplantation: Secondary Analysis of Blood and Marrow Transplant Clinical Trials Network 0902 Data.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 22(11):2077-2083.. 2016.
NCCN Guidelines Insights: Survivorship, Version 1.2016.. Journal of the National Comprehensive Cancer Network : JNCCN. 14(6):715-24.. 2016.
Parent Outlook: How Parents View the Road Ahead as They Embark on Hematopoietic Stem Cell Transplantation for Their Child.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 22(1):104-111.. 2016.
Evaluation and treatment of insomnia in adult cancer survivorship programs.. Journal of cancer survivorship : research and practice.. 2016.
Patient-Reported Outcomes and Socioeconomic Status as Predictors of Clinical Outcomes Following Hematopoietic Stem Cell Transplantation: a Study From the BMT CTN 0902 Trial.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.. 2016.
Hot flashes in breast cancer survivors: Frequency, severity and impact.. Breast (Edinburgh, Scotland). 27:116-121.. 2016.
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: V. The 2014 Ancillary Therapy and Supportive Care Working Group Report.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.. 2015.
Outcomes and satisfaction after delivery of a breast cancer survivorship care plan: results of a multicenter trial.. Journal of oncology practice / American Society of Clinical Oncology. 11(2):e222-9.. 2015.
Valganciclovir for the prevention of complications of late cytomegalovirus infection after allogeneic hematopoietic cell transplantation: a randomized trial.. Annals of internal medicine. 162(1):1-10.. 2015.
Developing a risk prediction model for long-term physical and psychological functioning after hematopoietic cell transplantation.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.. 2015.
Resilience, health, and quality of life among long-term survivors of hematopoietic cell transplantation.. Cancer. 121(23):4250-4257.. 2015.
Multi-centre validation of the prognostic value of the haematopoietic cell transplantation- specific comorbidity index among recipient of allogeneic haematopoietic cell transplantation.. British journal of haematology. 170(1):574-83.. 2015.
Comorbidity-age index: a clinical measure of biologic age before allogeneic hematopoietic cell transplantation.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 32(29):3249-56.. 2014.
Survivorship: screening for cancer and treatment effects, version 2.2014.. Journal of the National Comprehensive Cancer Network : JNCCN. 12(11):1526-31.. 2014.
Pain in Cancer Survivors.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2014.
Psychological and Behavioral Approaches to Cancer Pain Management.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2014.
Survivorship: sleep disorders, version 1.2014.. Journal of the National Comprehensive Cancer Network : JNCCN. 12(5):630-42.. 2014.
Survivorship: sexual dysfunction (male), version 1.2013.. Journal of the National Comprehensive Cancer Network : JNCCN. 12(3):356-63.. 2014.
Resilience and psychosocial outcomes in parents of children with cancer.. Pediatric blood & cancer. 61(3):552-557.. 2014.