Stephen M. Schwartz
Ph.D., University of Washington, Epidemiology, 1990.
M.P.H., Yale University, Epidemiology, 1984.
B.A., University of Virginia, Biology, 1981.
The following paragraphs provide summaries of my research interests. More details can be found on my webpage, listed above.
My studies of the molecular epidemiology of oral squamous cell carcinoma (OSCC) explore the interplay of genetic, virologic, and lifestyle characteristics in both the etiology and prognosis of these cancers. Using data from a population-based case-control study, we have found that the risk of OSCC was related to serologic evidence of both HPV and HSV1 infection, particularly among cigarette smokers. In addition, we found that the detection of HPV DNA in OSCC is related to favorable patient survival. We are currently examining whether OSCC is related to polymorphisms in a variety of genes that are known or suspected of mediating the consequences of tobacco, alcohol, and viral exposures. Examples of genes we have or will study include GSTM1, GSTT1, GSTP1, CYP2E1, NQO1, NAT1, NAT2, EPHX, ADH3, XRCC3, XRCC1, AGT, and XPD. The results should enhance our knowledge of the interaction of environmental and inherited susceptibility to OSCC.
As part of a Program Project Grant headed by James McDougall, Ph.D., (Cancer Biology Program, FHCRC), I am studying factors related to the prognosis of cervical and other genital cancers. Our goal is to identify tumor markers and other characteristics that in the future may help clinicians predict which patients will develop recurrences and, potentially, target the application of therapies to women at highest risk of relapse. We have found that patients with HPV18-related cervical cancers have reduced survival, and recent immunohistochemical analyses of these tumors suggests that the combination of high cyclin E expression and HPV18 is associated with a particularly poor prognosis.
I have continued my long-standing interest in the etiology of uterine leiomyomata ("fibroids"). Leiomyomata are among the most common neoplasms that develop among women, and although benign, are the leading non-malignant indication for hysterectomy among pre-menopausalwomen. TULEP (The Uterine Leiomyomata Epidemiology Project) is a population-based case-control study we conducted to identify hormonal and hormonally-mediated risk factors for uterine leiomyomata, In addition to an extensive in-person interview focusing on lifestyle, medical, and reproductive characteristics, we collected biologic specimens to determine whether the risk of leiomyomata is related to: (1) urinary excretion of phytoestrogens (lignans, isoflavones); (2) serum organochlorine pesticideand polychlorinated biphenyl residues; and (3) germline polymorphisms in enzymes involved in hormone synthesis and metabolism.
I am conducting a population-based case-control study to test the hypothesis that inherited variation in genes involved in stimulating testicular steroidogenesis, synthesizing and metabolizing testosterone, and androgen signaling, is related to the risk of developing testicular germ cell carcinoma (TGCC). In addition to examining gene-gene interactions using the case-control data, we are studying whether blood levels of putative endocrine disrupting chemicals, such as p,p-DDE, pose an increased risk of TGCC among carriers of putative TGCC susceptibility alleles (e.g., large numbers of CAG repeats in the Androgen Receptor gene). We also are employing a case-parent triad design (by recruiting the mothers and fathers of our TGCC cases) to test the hypothesis that maternal carriership of susceptibility alleles in steroid metabolism and growth factor genes are related to TGCC risk.
American Association for Cancer Research
Society for Epidemiologic Research
1996-2002, Associate Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Epidemiology
1995-1996, Assistant Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Epidemiology
1990-1995, Affiliate Investigator, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Epidemiology
1990-1996, Assistant Professor, University of Washington, School of Public Health and Community Medicine, Epidemiology
1989-1989, Instructor, University of Washington, School of Public Health and Community Medicine, Epidemiology
1985-1990, Research Associate, Fred Hutchinson Cancer Research Center, Epidemiology
1984-1985, Research Associate, Fred Hutchinson Cancer Research Center, Cancer Surveillance System
Knowledge of Clinical Trial Availability and Reasons for Nonparticipation Among Adolescent and Young Adult Cancer Patients: A Population-based Study.. American journal of clinical oncology.. 2016.
A Birth Cohort Study of Maternal and Infant Serum PCB-153 and DDE Concentrations and Responses to Infant Tuberculosis Vaccination.. Environmental health perspectives. 124(6):813-21.. 2016.
Consumption of alcoholic beverages in adolescence and adulthood and risk of testicular germ cell tumor.. International journal of cancer.. 2016.
Re-detection vs. new acquisition of high-risk human papillomavirus in mid-adult women.. International journal of cancer.. 2016.
Mouthwash use and cancer of the head and neck: a pooled analysis from the International Head and Neck Cancer Epidemiology Consortium.. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 25(4):344-348.. 2016.
Survival and Gastrostomy Prevalence in Patients With Oropharyngeal Cancer Treated With Transoral Robotic Surgery vs Chemoradiotherapy.. JAMA otolaryngology-- head & neck surgery. 142(7):691-697.. 2016.
Who Treats Adolescents and Young Adults with Cancer? A Report from the AYA HOPE Study. Journal of adolescent and young adult oncology. 4(3):141-150.. 2015.
A population-based case-control study of genetic variation in cytokine genes associated with risk of cervical and vulvar cancers.. Gynecologic oncology. 139(1):90-6.. 2015.
Short-term natural history of high-risk human papillomavirus infection in mid-adult women sampled monthly.. International journal of cancer. Journal international du cancer.. 2015.
Blood lipids and colorectal polyps: testing an etiologic hypothesis using phenotypic measurements and Mendelian randomization.. Cancer causes & control : CCC. 26(3):467-73.. 2015.
Analysis of liquid bead microarray antibody assay data for epidemiologic studies of pathogen-cancer associations.. Journal of immunological methods.. 2015.
Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis.. International journal of epidemiology.. 2015.
Association of history of allergies and influenza-like infections with laryngeal cancer in a case-control study.. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery.. 2015.
Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction.. Nature. 518(7537):102-6.. 2015.
Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium.. International journal of epidemiology. 44(1):169-85.. 2015.
Incidence of testicular germ cell tumors among US men by census region.. Cancer. 121(23):4181-89.. 2015.
Epidemiology of Human Papillomavirus Detected in the Oral Cavity and Fingernails of Mid-Adult Women.. Sexually transmitted diseases. 42(12):677-85.. 2015.
Risk of congenital heart defects in the offspring of smoking mothers: a population-based study.. The Journal of pediatrics. 166(4):978-984.e2.. 2015.
Myelodysplastic syndrome and acute myeloid leukemia following adjuvant chemotherapy with and without granulocyte colony-stimulating factors for breast cancer.. Breast cancer research and treatment. 154(1):133-143.. 2015.
Inactivating mutations in NPC1L1 and protection from coronary heart disease.. The New England journal of medicine. 371(22):2072-82.. 2014.
Use of appropriate initial treatment among adolescents and young adults with cancer.. Journal of the National Cancer Institute. 106(11). 2014.
Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries.. International journal of cancer. Journal international du cancer.. 2014.