Effie Wang Petersdorf
Our laboratory is engaged in understanding MHC gene function using hematopoietic cell transplantation from unrelated donors as a model system. The role of the HLA system has been established in solid organ and stem cell transplantation as pivotal for the acceptance of the engrafted tissue. Historically, alloantisera have been used to discriminate epitopes that define HLA antigens. With the advent of PCR-based tools in the mid-1980s, it became clear that a single serologically-defined antigen could be encoded by several unique sequences. Our effort has been directed at designing robust DNA-based methods to assay these single nucleotide polymorphisms (SNPs) in class I HLA-A, B, C and class II DRB1, DQB1 and DPB1 genes. Application of these methods has allowed a more precise and complete characterization of patients and unrelated donors. This work has elucidated the functional role of class II SNPs in acute graft-versus-host disease (GVHD), the role of class I SNPs in graft failure, and the importance of number of donor or recipient disparities in defining the overall success of unrelated donor transplantation. We have extended our studies to build an international effort among transplant centers, donor registries and laboratories to understand permissible mismatches. Hypotheses that we are currently testing include the identification of non-HLA SNPs having functional relevance in transplantation, and the application of molecular methods to understand the nature of SNPs having relevance in solid tumor model systems.
HLA mismatching in transplantation.. Blood. 125(7):1058-9.. 2015.
High HLA-DP Expression and Graft-versus-Host Disease.. The New England journal of medicine. 373(7):599-609.. 2015.
Center for International Blood and Marrow Transplant Research chronic graft-versus-host disease risk score predicts mortality in an independent validation cohort.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 21(4):640-5.. 2015.
Association between Ctl Precursor Frequency to Hla-C Mismatches and Hla-C Antigen Cell Surface Expression. Tissue Antigens. 84:42-42.. 2014.
Comparison of statistics in association tests of genetic markers for survival outcomes.. Statistics in medicine.. 2013.
The major histocompatibility complex: a model for understanding graft-versus-host disease.. Blood. 122(11):1863-72.. 2013.
Genetic variation in the TLR and NF-κB pathways and cervical and vulvar cancer risk: A population-based case-control study.. International journal of cancer. Journal international du cancer.. 2013.
Significance of Ethnicity in the Risk of Acute Graft-versus-Host Disease and Leukemia Relapse after Unrelated Donor Hematopoietic Stem Cell Transplantation.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 19(8):1197-203.. 2013.
Common sequence variants in chemokine-related genes and risk of breast cancer in post-menopausal women.. International journal of molecular epidemiology and genetics. 4(4):218-27.. 2013.
Incidence, risk factors and outcomes of sclerosis in patients with chronic graft-versus-host disease.. Blood. 121(25):5098-103.. 2013.
Nucleotide variation in IL-10 and IL-12 and their receptors and cervical and vulvar cancer risk: A hybrid case-parent triad and case-control study.. International journal of cancer. Journal international du cancer. 133(1):201-13.. 2013.
Genetic variation in CD83 and risks of cervical and vulvar cancers: A population-based case-control study.. Gynecologic oncology. 124(3):525-528.. 2012.
MHC-Resident Variation Affects Risks After Unrelated Donor Hematopoietic Cell Transplantation.. Science translational medicine. 4(144):144ra101.. 2012.
Classifying Cytogenetics in Patients with Acute Myelogenous Leukemia in Complete Remission Undergoing Allogeneic Transplantation: A Center for International Blood and Marrow Transplant Research Study.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 18(2):280-288.. 2012.
Effect of T-cell-epitope matching at HLA-DPB1 in recipients of unrelated-donor haemopoietic-cell transplantation: a retrospective study.. The lancet oncology. 13(4):366-374.. 2012.
Of genes, blocks, and haplotypes.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 18(4):494-6.. 2012.
Genotyping of single nucleotide polymorphisms by 5' nuclease allelic discrimination.. Methods in molecular biology (Clifton, N.J.). 882:173-82.. 2012.
Genetic variation in proinflammatory cytokines IL6, IL6R, TNF-region, and TNFRSF1A and risk of breast cancer.. Breast cancer research and treatment. 129(3):887-899.. 2011.