Amanda G. Paulovich

Appointments and Affiliations

 
 
Fred Hutchinson Cancer Research Center
Clinical Research Division
Early Detection Initiative Director
Member, Appointed: 2016
 
University of Washington
School of Medicine
Department of Medicine
Division of Oncology
Professor, Appointed: 2015
 
University of Washington
Graduate School
Molecular and Cellular Biology Program
Associate Professor, Appointed: 2007
Professional Headshot of Amanda G. Paulovich

Mailing Address

1100 Fairview Avenue North
E2-112
P.O. Box 19024
Seattle, Washington 98109-1024
United States

Contact

Phone: (206) 667-1912
Fax: (206) 667-2277
apaulovi@fhcrc.org
http://labs.fhcrc.org/paulovich/index.html

Degrees

Fellowship, Dana Farber Cancer Institute, Medical Oncology, 2004.
Postdoctoral Fellowship, MIT-Whitehead Center for Genomic Research, Computational Biology (Dr. Eric Lander), 2003.
Residency, Massachusetts General Hospital, Internal Medicine, 2000.
M.D., University of Washington, 1998.
Ph.D., University of Washington, Genetics (Dr. Leland Hartwell), 1996.
B.S., Carnegie Mellon University, Biological Sciences, 1988.

Research Interests

As an oncologist, Dr. Amanda Paulovich was struck by the paucity of quantitative assays for measuring clinically relevant phenotypes in her patients, and the limitations that this put on her ability to practice "precision medicine." Out of these experiences, she became passionate about developing technologies and strategies for translation of novel diagnostics and therapeutics to enable precision medicine. Genomic data has taken us a long way towards understanding cancer biology, but we still are unable to effectively predict curative therapies for patients. It is likely that some of the missing biology lies in the cancer proteome. Thus, the inability to quantitatively measure most human proteins is a major obstacle to clinical translation of biomarkers and the development of new therapeutics. To overcome this roadblock, her laboratory at Fred Hutch has spearheaded the development of targeted proteomic assays utilizing Multiple Reaction Monitoring Mass Spectrometry (MRM-MS), which provides precise and highly specific quantification of proteins with assays that can be multiplexed, standardized, reproduced, and shared across laboratories and instrument platforms (unlike conventional immunoassay methods). Having solved the roadblock, her well-established team is now leveraging this technology platform to develop transformative tools (multiplex protein assays) that will fundamentally change biomedical research and lead to improvements in patient diagnosis and treatment by facilitating precision medicine.

Memberships

American Chemical Society (ACS)
Radiation Research Society (RRS)
American Society for Mass Spectrometry (ASMS)
American Association for Cancer Research (AACR)
American Association for Clinical Chemistry (AACC)
American Society for Biochemistry and Molecular Biology (ASBMB)
American Society for Clinical Investigation (ASCI)
Human Proteome Organization (HUPO)
FHCRC/UW Cancer Consortium
FHCRC Proteomics Core Faculty Advisory Committee
Member, Editorial Board of Molecular and Cellular Proteomics
Member, Editorial Board of Clinical Chemistry

Honors and Awards

2015, Distinguished Achievement in Proteomic Sciences Award from the International Human Proteome Organization
2014, Life Science Innovation Northwest (LSINW) Women to Watch in Life Science Award
2012, Inducted to American Society for Clinical Investigation (ASCI)
2005, Roger E. Moe Award for Translational Research
2002, Damon Runyon Research Fellowship, Abbott Fellow
1992, Merck Distinguished Fellow Award
1989, HHMI Research Fellowship
1988, Carnegie Mellon Award for Outstanding Research
1987, Genetics Society of America Undergraduate Research Fellowship
1986, βββ Biological Honor Society

Previous Positions

2010-2016, Associate Professor, Department of Medicine/Division of Oncology, University of Washington School of Medicine
2005-2010, Assistant Professor, Department of Medicine/Division of Oncology, University of Washington School of Medicine
2009-2015, Associate Member, Fred Hutchinson Cancer Research Center, Clinical Research Division
2003-2009, Assistant Member, Fred Hutchinson Cancer Research Center, Clinical Research Division

Recent Publications

2016
Paulovich AG, Whiteaker JR.  2016.  Quantifying the human proteome.. Nature biotechnology. 34(10):1033-1034.
2015
2014
2013
2012