M.D., New York Medical College, 1989.
Ph.D., University of Washington, Epidemiology, 1982.
Prevention of new and recurrent breast and other cancer through physical activity, diet and chemoprevention.
Dr. McTiernan's research focuses on identifying ways to prevent new or recurrent cancer with a particular focus on weight control, physical activity, and chemoprevention. She is Principal Investigator of the Seattle TREC Center investigating mechanisms of energy balance and cancer prevention. She leads over twenty five scientists in transdisciplinary reasearch to elucidate the pathways linking components of energy balance to the cancer process. The five projects and four cores incorporate several different study designs, with contributions of scientists from medicine, cell biology, animal models, immunology, biostatistics, mathematics, exercise physiology, and behavioral science.
Dr. McTiernan is also Principal Investigator of a randomized controlled clinical trial of a one-year aerobic exercise intervention to compare the effects over one year of two lifestyle interventions in 503 postmenopausal women: (1) a moderate-intensity aerobic exercise intervention, and (2) a reduced-calorie diet plus moderate-intensity aerobic exercise intervention. She is Principal Investigator of the Seattle site of Health, Eating, Activity, and Lifestyle (HEAL) Study, which is assessing associations among anthropometrics, fat mass amount and distribution, endogenous sex and metabolic hormones, diet, and physical activity on prognostic factors in breast cancer patients. Dr. McTiernan is Principal Investigator of the Seattle site of the ExCel trial which is testing the effect of exemestane, an aromatase inhibitor, on breast cancer prevention, and she leads a randomized clinical trial testing aspirin effect on breast cancer biomarkers.
Previously she has conducted a randomized controlled clinical trial of a one-year aerobic exercise intervention vs. stretch control in 173 postmenopausal women. The primary aim of this study was to assess the effect of exercise on endogenous sex hormones that have been associated with increased risk for breast cancer. Ongoing ancillary studies test the effect of aerobic exercise on immune function and other biomarkers of breast cancer risk.
She is also been Principal Investigator of a randomized clinical trial to test the effect of a one-year aerobic exercise intervention vs. control on colorectal cell proliferation, apoptosis, and prostaglandin content, and on other biomarkers of colon cancer risk in 200 men and women with adenomatous colon polyps.
Dr. McTiernan was a co-Investigator in the Women's Health Initiative (WHI), and directed clinical outcomes efforts at the WHI Clinical Coordinating Center. She has conducted an analysis of physical activity and breast cancer incidence in the WHI Observational Study cohort of over 90,000 women and has collaborated on many additional analyses.
Dr. McTiernan has considerable experience with recruitment, retention, adherence, and endpoints in large-scale medication clinical trials (e.g. the Women's Health Initiative hormone therapy and calcium/vitamin D trials). She has expertise in Women's Health issues. She is co-investigator of the Seattle STAR trial, hence has experience with clinical trials using SERMS.
University of Washington Residency Training Internal Medicine 1992
American College of Epidemiology
American Society of Preventive Oncology
Society for Epidemiologic Research
Effects of vitamin D supplementation during weight loss on sex hormones in postmenopausal women.. Menopause (New York, N.Y.). 23(6):645-652.. 2016.
Cyclic endogenous estrogen and progesterone vary by mammographic density phenotypes in premenopausal women.. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 25(1):9-18.. 2016.
Associations of sex steroid hormones with mortality in women with breast cancer.. Breast cancer research and treatment. 155(3):559-67.. 2016.
Effects of Vitamin D3 Supplementation on Lean Mass, Muscle Strength, and Bone Mineral Density During Weight Loss: A Double-Blind Randomized Controlled Trial.. Journal of the American Geriatrics Society.. 2016.
Lipoprotein subfractions by nuclear magnetic resonance are associated with tumor characteristics in breast cancer.. Lipids in health and disease. 15(1):56.. 2016.
Circulating Adipokines and Inflammatory Markers and Postmenopausal Breast Cancer Risk.. Journal of the National Cancer Institute. 107(9). 2015.
High-Density Lipoprotein-Cholesterol, daily estradiol and progesterone, and mammographic density phenotypes in premenopausal women.. Cancer prevention research (Philadelphia, Pa.).. 2015.
Effect of Vitamin D3 supplementation in combination with weight loss on inflammatory biomarkers in postmenopausal women: a randomized controlled trial.. Cancer prevention research (Philadelphia, Pa.). 8(7):628-35.. 2015.
Alcohol consumption, endogenous estrogen and mammographic density among premenopausal women.. Breast cancer research : BCR. 17:103.. 2015.
Risk Reduction from Weight Management and Physical Activity Interventions.. Advances in experimental medicine and biology. 862:193-212.. 2015.
Predicting Adherence of Adults to a 12-Month Exercise Intervention.. Journal of physical activity & health. 11(7):1304-12.. 2014.
Effects of physical activity on melatonin levels in previously sedentary men and women.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.. 2014.
Change in Peripheral Blood Leukocyte Telomere Length and Mortality in Breast Cancer Survivors.. Journal of the National Cancer Institute.. 2014.
Vitamin D3 supplementation during weight loss: a double-blind randomized controlled trial.. The American journal of clinical nutrition.. 2014.
No effect of weight loss on LINE-1 methylation levels in peripheral blood leukocytes from postmenopausal overweight women.. Obesity (Silver Spring, Md.).. 2014.
Aspirin and Serum Estrogens in Postmenopausal Women: a Randomized Controlled Clinical Trial.. Cancer prevention research (Philadelphia, Pa.).. 2014.
Walking speed, physical activity, and breast cancer in postmenopausal women.. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 23(1):49-52.. 2014.
Effect of a 12-month Exercise Intervention on Serum Biomarkers of Angiogenesis in Postmenopausal Women: a randomized controlled trial.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.. 2014.
Plasma polychlorinated biphenyl concentrations and immune function in postmenopausal women.. Environmental research. 131C:174-180.. 2014.
Gene variations in oestrogen pathways, CYP19A1, daily 17β-estradiol and mammographic density phenotypes in premenopausal women.. Breast cancer research : BCR. 16(6):499.. 2014.