Wendy M. Leisenring
Sc.D., Harvard University, Biostatistics, 1992.
M.S., Harvard University, Biostatistics, 1990.
A.B., Bryn Mawr College, Mathematics, 1986.
Within the framework of a variety of collaborative and methodological projects, my overall research goals are to ensure that scientific research is carried out that utilizes appropriate statistical methodology. Sometimes this is achieved through application of existing statistical methods and in other instances it involves development of new methodology. My research encompasses several collaborative and methodological subject areas: clinical research related to stem cell transplantation, reproductive epidemiology and developing new statistical methods for the analysis of medical diagnostic test data.
A major focus of my research is collaborative work with clinical investigators who are based in the Center's Clinical Research Division (CRD). CRD is world renown for its pioneering work in stem cell transplantation where the procedure was first used approximately 30 years ago. In collaboration with principal investigators from several large program project grants in the CRD, I carry out the design and analysis of Phase I, II and III clinical trials which aim to further expand and improve our ability to treat patients with a wide range of diseases and prognoses. Over the long history of transplantation at the Center, our group has also developed a large database of patient data that allows us to carry out retrospective analyses to generate hypotheses for future prospective studies.
For patients undergoing stem cell transplantation, infection is a very serious development and more accurate and earlierdetection of disease is an important research topic amongst infectious disease researchers. More globally, diagnostic and screening programs are becoming a large and costly component of our health care system. It is therefore important that research leading to the implementation of new tests be rigorous in determining the accuracy of the tests. A primary goal of my methodological research is to develop statistical methods that allow researchers to answer relevant clinical questions about diagnostic tests. We have described marginal regression methods for the comparison of multiple diagnostic tests and evaluation of covariate impacts on sensitivity and specificity parameters when one or more test outcomes are obtained on each subject studied. Additionally, we developed a new regression methodology for diagnostic likelihood ratios, quantities that describe the degree to which the outcome of a diagnostic test revises the pre-test odds of disease. Most recently, we have developed a statistical test for the comparison of predictive values of diagnostic tests when the data was obtained under paired study designs.
American Statistical Association
Society for Clinical Trials
Honors and Awards
1990-1991, Training Grant Recipient, National Institute of Environmental Health
1989-1991, Harvard University Teaching Fellow,
1988-1990, Training Grant Recipient, National Cancer Institute
1992, Student Prize for Best Paper, ENAR Biometrics Society
1992, Travel Award Recipient, ENAR Biometrics Society
1993, Teratology Society Young Investigators Travel Award,
1994, Best Presentation Award, Society of Toxicology, Risk Assessment Specialty Section
2002-2008, Affiliate Associate Professor, University of Washington, Department of Biostatistics
2001-2007, Associate Member, Fred Hutchinson Cancer Research Center, Clinical Research Division, Clinical Statistics
2001-2007, Associate Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Biostatistics
1998-2002, Affiliate Assistant Professor, University of Washington, Biostatsitics
1997-2001, Assistant Member, Fred Hutchinson Cancer Research Center, Clinical Research Division, Clinical Statistics
1994-1997, Associate in Clinical Research, Fred Hutchinson Cancer Research Center, Clinical Research Division, Clinical Statistics
1993-1994, Visiting Investigator, Fred Hutchinson Cancer Research Center
Psychological outcomes of siblings of cancer survivors: a report from the Childhood Cancer Survivor Study.. Psycho-oncology. 20(12):1259-68.. 2011.
Occurrence of multiple subsequent neoplasms in long-term survivors of childhood cancer: a report from the childhood cancer survivor study.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 29(22):3056-64.. 2011.
Treatment of Fanconi anemia patients using fludarabine and low-dose TBI, followed by unrelated donor hematopoietic cell transplantation.. Bone marrow transplantation. 46(4):539-44.. 2011.
Pregnancy, microchimerism, and the maternal grandmother.. PloS one. 6(8):e24101.. 2011.
Adolescent behavior and adult health status in childhood cancer survivors.. Journal of cancer survivorship : research and practice. 4(3):210-7.. 2010.
Inconsistent mammography perceptions and practices among women at risk of breast cancer following a pediatric malignancy: a report from the Childhood Cancer Survivor Study.. Cancer causes & control : CCC. 21(10):1585-95.. 2010.
Outcome of allogeneic hematopoietic cell transplantation from HLA-identical siblings for severe aplastic anemia in patients over 40 years of age.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 16(10):1411-8.. 2010.
Unemployment among adult survivors of childhood cancer: a report from the childhood cancer survivor study.. Medical care. 48(11):1015-25.. 2010.
Prevalence and predictors of posttraumatic stress disorder in adult survivors of childhood cancer.. Pediatrics. 125(5):e1124-34.. 2010.
Prospective predictors of return to work in the 5 years after hematopoietic cell transplantation.. Journal of cancer survivorship : research and practice. 4(1):33-44.. 2010.
Subsequent neoplasms in 5-year survivors of childhood cancer: the Childhood Cancer Survivor Study.. Journal of the National Cancer Institute. 102(14):1083-95.. 2010.
Fertility of male survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 28(2):332-9.. 2010.
Associations between polymorphisms in glucuronidation and sulfation enzymes and mammographic breast density in premenopausal women in the United States.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 19(2):537-46.. 2010.
Long-term survivors of childhood Ewing sarcoma: report from the childhood cancer survivor study.. Journal of the National Cancer Institute. 102(16):1272-83.. 2010.
Attentional and executive dysfunction as predictors of smoking within the Childhood Cancer Survivor Study cohort.. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 12(4):344-54.. 2010.
The impact of donor type and ABO incompatibility on transfusion requirements after nonmyeloablative haematopoietic cell transplantation.. British journal of haematology. 149(1):101-10.. 2010.
Associations between endogenous sex hormone levels and mammographic and bone densities in premenopausal women.. Cancer causes & control : CCC. 20(7):1039-53.. 2009.
Low relapse without excessive transplant-related mortality following myeloablative cord blood transplantation for acute leukemia in complete remission: a matched cohort analysis.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 15(9):1122-9.. 2009.
Predictors of marriage and divorce in adult survivors of childhood cancers: a report from the Childhood Cancer Survivor Study.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 18(10):2626-35.. 2009.