Johanna W. Lampe
Ph.D., University of Minnesota, Nutrition Sciences, 1990.
B.S., University of Minnesota, Nutrition and Dietetics, 1982.
R.D., University of Minnesota, Nutrition and Dietetics, 1982.
My research interests relate to understanding the mechanisms by which components of diet, particularly constituents of plant foods, alter risk factors for cancer. We use controlled dietary studies and other types of interventions in humans to examine biologic responses to diet and to evaluate biomarkers of dietary exposure. Several of our recent studies have focused on gene-diet interactions in relation to biotransformation enzyme activities. Numerous low-penetrance, high-prevalence genetic polymorphisms in metabolizing enzymes, such as the cytochromes P450 and conjugating enzymes (e.g., glutathione S-transferases, UDP-glucuronosyltransferases), can contribute to interindividual variation in enzyme activities. Many of these enzymes metabolize and inactivate potential carcinogens and cancer-promoting agents. They can also metabolize various compounds in plant foods and can be induced by specific phytochemicals. The relationship between genetic differences in enzyme activities and differences in plant food intake may be an important determinant of cancer susceptibility. Controlled feeding studies in humans are a useful method to examine these interactions.
The Lampe laboratory also investigates the metabolism and activities of isoflavones and lignans (estrogenic compounds found in soybeans and other plant foods). The phytoestrogens, like other plant food constituents, are made more biologically active when they undergo bacterial metabolism in the colon. Differences in colonic bacterial populations and aspects of diet that alter colonic environment influence exposure to potential chemoprotective agents. We are using cross-sectional, intervention, and in vitro studies to determine how dietary factors contribute to these differences in metabolism, whether metabolism can be altered by diet, and what are the biologic implications of these metabolic differences, particularly in relation to colorectal neoplasia. The laboratory also measures phytoestrogen concentrations in biologic samples for several large-scale epidemiologic studies.
American Association for Cancer Research
American Dietetic Association
American Society for Nutritional Sciences
Society for Experimental Biology and Medicine
2002-2006, Research Associate Professor, University of Washington
1999-2004, Associate Member, Fred Hutchinson Cancer Research Center
1999-2002, Research Assistant Professor, University of Washington
1998-1999, Assistant Member, Fred Hutchinson Cancer Research Center
1994-1998, Associate, Fred Hutchinson Cancer Research Center
1993-1994, Research Associate, University of Minnesota, Food, Agricultural & Natural Resource Sciences, College of-Minneapolis/St. Paul, Food Science & Nutrition
Genetic variation in metallothionein and metal-regulatory transcription factor 1 in relation to urinary cadmium, copper, and zinc.. Toxicology and applied pharmacology.. 2015.
Aspirin Reduces Plasma Concentrations of the Oncometabolite 2-Hydroxyglutarate: Results of a Randomized, Double-Blind, Crossover Trial.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.. 2015.
A cross-sectional study of equol producer status and self-reported vasomotor symptoms.. Menopause (New York, N.Y.). 22(5):489-95.. 2015.
Enterolignan-producing phenotypes are associated with increased gut microbial diversity and altered composition in premenopausal women in the United States.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 24(3):546-54.. 2015.
Metabolomics and transcriptomics identify pathway differences between visceral and subcutaneous adipose tissue in colorectal cancer patients: the ColoCare study.. The American journal of clinical nutrition.. 2015.
Cruciferous vegetables have variable effects on biomarkers of systemic inflammation in a randomized controlled trial in healthy young adults.. The Journal of nutrition. 144(11):1850-7.. 2014.
Associations between Dietary Intake of Fruits and Vegetables in relation to Urinary Estrogen DNA Adduct Ratio.. Open journal of preventive medicine. 4(6):429-437.. 2014.
Intake of Long-Chain ω-3 Fatty Acids From Diet and Supplements in Relation to Mortality.. American journal of epidemiology.. 2014.
Associations Between Glucosamine and Chondroitin Supplement Use and Biomarkers of Systemic Inflammation.. Journal of alternative and complementary medicine (New York, N.Y.).. 2014.
Gut microbes, diet, and cancer.. Cancer treatment and research. 159:377-99.. 2014.
Long-Chain Omega-3 Polyunsaturated Fatty Acid Intake and Risk of Colorectal Cancer.. Nutrition and cancer.. 2013.
Comparison and validation of 2 analytical methods for measurement of urinary sucrose and fructose excretion.. Nutrition research (New York, N.Y.). 33(9):696-703.. 2013.
Metabolomic profiling of urine: response to a randomised, controlled feeding study of select fruits and vegetables, and application to an observational study.. The British journal of nutrition. :1-11.. 2013.
Premenopausal vasomotor symptoms in an ethnically diverse population.. Menopause (New York, N.Y.).. 2013.
Sulforaphane is not an effective antagonist of the human pregnane X-receptor in vivo.. Toxicology and applied pharmacology. 266(1):122-31.. 2013.
Gastrointestinal effects of resistant starch, soluble maize fibre and pullulan in healthy adults.. The British journal of nutrition. :1-7.. 2013.
Inter-individual differences in response to dietary intervention: integrating omics platforms towards personalised dietary recommendations.. The Proceedings of the Nutrition Society. :1-12.. 2013.
Dietary supplementation of glucosamine sulfate attenuates intestinal inflammation in a mouse model of experimental colitis.. Journal of gastroenterology and hepatology.. 2013.
Specialty supplement use and biologic measures of oxidative stress and DNA damage.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.. 2013.