Johanna W. Lampe
Ph.D., University of Minnesota, Nutrition Sciences, 1990.
B.S., University of Minnesota, Nutrition and Dietetics, 1982.
R.D., University of Minnesota, Nutrition and Dietetics, 1982.
My research interests relate to understanding the mechanisms by which components of diet, particularly constituents of plant foods, alter risk factors for cancer. We use controlled dietary studies and other types of interventions in humans to examine biologic responses to diet and to evaluate biomarkers of dietary exposure. Several of our recent studies have focused on gene-diet interactions in relation to biotransformation enzyme activities. Numerous low-penetrance, high-prevalence genetic polymorphisms in metabolizing enzymes, such as the cytochromes P450 and conjugating enzymes (e.g., glutathione S-transferases, UDP-glucuronosyltransferases), can contribute to interindividual variation in enzyme activities. Many of these enzymes metabolize and inactivate potential carcinogens and cancer-promoting agents. They can also metabolize various compounds in plant foods and can be induced by specific phytochemicals. The relationship between genetic differences in enzyme activities and differences in plant food intake may be an important determinant of cancer susceptibility. Controlled feeding studies in humans are a useful method to examine these interactions.
The Lampe laboratory also investigates the metabolism and activities of isoflavones and lignans (estrogenic compounds found in soybeans and other plant foods). The phytoestrogens, like other plant food constituents, are made more biologically active when they undergo bacterial metabolism in the colon. Differences in colonic bacterial populations and aspects of diet that alter colonic environment influence exposure to potential chemoprotective agents. We are using cross-sectional, intervention, and in vitro studies to determine how dietary factors contribute to these differences in metabolism, whether metabolism can be altered by diet, and what are the biologic implications of these metabolic differences, particularly in relation to colorectal neoplasia. The laboratory also measures phytoestrogen concentrations in biologic samples for several large-scale epidemiologic studies.
American Association for Cancer Research
American Dietetic Association
American Society for Nutritional Sciences
Society for Experimental Biology and Medicine
2002-2006, Research Associate Professor, University of Washington
1999-2004, Associate Member, Fred Hutchinson Cancer Research Center
1999-2002, Research Assistant Professor, University of Washington
1998-1999, Assistant Member, Fred Hutchinson Cancer Research Center
1994-1998, Associate, Fred Hutchinson Cancer Research Center
1993-1994, Research Associate, University of Minnesota, Food, Agricultural & Natural Resource Sciences, College of-Minneapolis/St. Paul, Food Science & Nutrition
Measurement of Circulating Phospholipid Fatty Acids: Association between Relative Weight Percentage and Absolute Concentrations.. Journal of the American College of Nutrition. 35(7):647-656.. 2016.
Reliability of plasma lipopolysaccharide-binding protein (LBP) from repeated measures in healthy adults.. Cancer causes & control : CCC. 27(9):1163-1166.. 2016.
Changes in relative and absolute concentrations of plasma phospholipid fatty acids observed in a randomized trial of Omega-3 fatty acids supplementation in Uganda.. Prostaglandins, leukotrienes, and essential fatty acids. 114:11-16.. 2016.
Characterization of the gut microbiome in epidemiologic studies: the multiethnic cohort experience.. Annals of epidemiology. 26(5):373-379.. 2016.
Plasma equol concentration is not associated with breast cancer and fibrocystic breast conditions among women in Shanghai, China.. Nutrition research (New York, N.Y.). 36(8):863-871.. 2016.
Factors Associated with Multiple Biomarkers of Systemic Inflammation.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.. 2016.
Dietary biomarker evaluation in a controlled feeding study in women from the Women's Health Initiative cohort.. The American journal of clinical nutrition.. 2016.
Soy isoflavone intake is associated with risk of Kawasaki disease.. Nutrition research (New York, N.Y.). 36(8):827-834.. 2016.
Aspirin Reduces Plasma Concentrations of the Oncometabolite 2-Hydroxyglutarate: Results of a Randomized, Double-Blind, Crossover Trial.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.. 2015.
A cross-sectional study of equol producer status and self-reported vasomotor symptoms.. Menopause (New York, N.Y.). 22(5):489-95.. 2015.
Enterolignan-producing phenotypes are associated with increased gut microbial diversity and altered composition in premenopausal women in the United States.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 24(3):546-54.. 2015.
Metabolic responses to a traditional Mexican diet compared with a commonly consumed US diet in women of Mexican descent: a randomized crossover feeding trial.. The American journal of clinical nutrition.. 2015.
Genetic variation in metallothionein and metal-regulatory transcription factor 1 in relation to urinary cadmium, copper, and zinc.. Toxicology and applied pharmacology. 289(3):381-388.. 2015.
Development and Use of a Traditional Mexican Diet Score in Relation to Systemic Inflammation and Insulin Resistance among Women of Mexican Descent.. The Journal of nutrition. 145(12):2732-40.. 2015.
Metabolomics and transcriptomics identify pathway differences between visceral and subcutaneous adipose tissue in colorectal cancer patients: the ColoCare study.. The American journal of clinical nutrition. 102(2):433-43.. 2015.
Cruciferous vegetables have variable effects on biomarkers of systemic inflammation in a randomized controlled trial in healthy young adults.. The Journal of nutrition. 144(11):1850-7.. 2014.