Andrea Z. Lacroix
Ph.D., University of North Carolina, 1984.
Dr. Andrea LaCroix has expertise in epidemiologic methods; large randomized controlled clinical trials; osteoporosis and fracture; women's health; aging; and cardiovascular disease. Dr. LaCroix is Co-Principal Investigator of the Women's Health Initiative Clinical Coordinating Center at the Fred Hutchinson Cancer Research Center; Scientific Investigator at the Center for Health Studies, Group Health Cooperative of Puget Sound; and Professor of Epidemiology at the University of Washington in Seattle. Her research focuses on prevention of osteoporosis and fracture in women of all ages, as well as prevention of coronary disease and cancer. She has published widely on these topics with an emphasis on identifying effective pharmacologic and lifestyle interventions for healthy aging among women.
In the past year, Dr. LaCroix published the results of a three-year randomized controlled trial started in 1993 showing that low dose hydrochlorothiazide preserved bone density at the hip and spine in older adults. She also presented the results of an analysis from the Women's Health Initiative Observational Study, a prospective cohort study of 93,724 women, showing that women who took statin medications for lipid lowering had similar rates of hip, lower arm/wrist and other clinical fractures as women who did not take statin medications. These findings contrast with earlier studies showing a benefit of statins on risk of hip fracture. Dr. LaCroix and her colleagues have developed and tested a workbook designed to assist women with making informed decisions about whether or not to take hormone replacement therapy. Evaluation of the workbook with a randomized controlled trial showed significant improvements in knowledge about HRT among women who received the workbook. This document will be published in the spring 2001 catalogue of the US Government Printing Office and will also be disseminated through a website under development by the Centers for Disease Control. Dr. LaCroix is collaborating as the senior investigator on a new randomized trial testing the effects of selected herbal remedies on vasomotor symptoms, cardiovascular risk factors and bone density in symptomatic perimenopausal women.
American Heart Association
American Public Health Association
American Society for Bone and Mineral Research
Society for Epidemiologic Research
The Objective Physical Activity and Cardiovascular Disease Health in Older Women (OPACH) Study.. BMC public health. 17(1):192.. 2017.
DNA methylation-based measures of biological age: meta-analysis predicting time to death.. Aging. 8(9):1844-1865.. 2016.
Kidney Function and Disability-Free Survival in Older Women.. Journal of the American Geriatrics Society.. 2016.
Replication of Genome-Wide Association Study Findings of Longevity in White, African American, and Hispanic Women: The Women's Health Initiative.. The journals of gerontology. Series A, Biological sciences and medical sciences.. 2016.
Cross-sectional association of endogenous steroid hormone, sex hormone-binding globulin, and precursor steroid levels with hemostatic factor levels in postmenopausal women.. Journal of thrombosis and haemostasis : JTH.. 2016.
Long-term oral bisphosphonate use in relation to fracture risk in postmenopausal women with breast cancer: findings from the Women's Health Initiative.. Menopause (New York, N.Y.). 23(11):1168-1175.. 2016.
Urinary Cadmium and Risk of Invasive Breast Cancer in the Women's Health Initiative.. American journal of epidemiology. 183(9):815-23.. 2016.
The Impact of Multimorbidity and Coronary Disease Comorbidity on Physical Function in Women Aged 80 Years and Older: The Women's Health Initiative.. The journals of gerontology. Series A, Biological sciences and medical sciences. 71 Suppl 1:S54-61.. 2016.
Comparison of Frailty Phenotypes for Prediction of Mortality, Incident Falls, and Hip Fracture in Older Women.. Journal of the American Geriatrics Society.. 2016.
A yoga & exercise randomized controlled trial for vasomotor symptoms: Effects on heart rate variability.. Complementary therapies in medicine. 26:66-71.. 2016.
A pilot study combining Go4Life® materials with an interactive voice response system to promote physical activity in older women.. Journal of women & aging. :1-9.. 2016.
Increase in Fracture Risk Following Unintentional Weight Loss in Postmenopausal Women: The Global Longitudinal Study of Osteoporosis in Women.. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2016.
Aging Well Among Women Veterans Compared With Non-Veterans in the Women's Health Initiative.. The Gerontologist. 56 Suppl 1:S14-26.. 2016.
Association Between Anthropometric Measures and Long-Term Survival in Frail Older Women: Observations from the Women's Health Initiative Study.. Journal of the American Geriatrics Society. 64(2):277-84.. 2016.
Association Between Chronic Conditions and Physical Function Among Veteran and Non-Veteran Women With Diabetes.. The Gerontologist. 56 Suppl 1:S112-25.. 2016.
Fracture Rates and Bone Density Among Postmenopausal Veteran and Non-Veteran Women From the Women's Health Initiative.. The Gerontologist. 56 Suppl 1:S78-90.. 2016.
The cross-sectional association between vasomotor symptoms and hemostatic parameter levels in postmenopausal women.. Menopause (New York, N.Y.).. 2016.
Identification of Risk Factors for Mortality and Poor-Quality-of-Life Survival in Frail Older Women Participating in the Women's Health Initiative Observational Study.. Journal of the American Geriatrics Society. 64(4):831-7.. 2016.
An Activity Index for Raw Accelerometry Data and Its Comparison with Other Activity Metrics.. PloS one. 11(8):e0160644.. 2016.
Prospective Analysis of Health and Mortality Risk in Veteran and Non-Veteran Participants in the Women's Health Initiative.. Women's health issues : official publication of the Jacobs Institute of Women's Health.. 2015.
Anticholinergic Medication Use and Fractures in Postmenopausal Women: Findings from the Women's Health Initiative.. Drugs & aging. 32(9):755-63.. 2015.
Symptom clusters among MsFLASH clinical trial participants.. Menopause (New York, N.Y.).. 2015.
Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.. Nature. 526(7571):112-7.. 2015.