Keith R. Jerome
M.D., Duke University, 1993.
Ph.D., Duke University, Immunology, 1992.
B.S., Georgetown College, Chemistry, 1985.
My research focuses on chronic and latent viruses, their immune evasion mechanisms, and potential curative therapeutic approaches to these infections. Recent work involves the use of DNA editing enzymes such as homing endonucleases and zinc finger nucleases to specifically target latent viral DNA for cleavage and inactivation. This approach may allow precise elimination of functional viral DNA from infected cell reservoirs, offering the prospect of cure for HIV, hepatitis B, herpes simplex, and human papillomavirus infections.
Clinically, I serve as Director of the University of Washington molecular virology laboratory, and consult regarding all aspects of virology testing. Specific areas of interest include real time PCR, automation of nucleic acid extraction, and diagnosis of disease caused by herpesviruses, enterovirus, JC and BK viruses, parvovirus B19, and hepatitis virus.
American Society for Microbiology
Infectious Diseases Society of America
Bronchoalveolar Lavage DNA Quantification in Cytomegalovirus Pneumonia after Hematopoietic Cell Transplantation.. The Journal of infectious diseases.. 2017.
In vivo disruption of latent HSV by designer endonuclease therapy.. JCI insight. 1(14). 2016.
Attitudes and Willingness to Assume Risk of Experimental Therapy to Eradicate Genital Herpes Simplex Virus Infection.. Sexually transmitted diseases. 43(9):566-71.. 2016.
Rapid metagenomic next-generation sequencing during an investigation of hospital-acquired human parainfluenza virus 3 infections.. Journal of clinical microbiology.. 2016.
Superiority of digital RT-PCR over real-time RT-PCR for quantitation of highly divergent human rhinoviruses.. Journal of clinical microbiology.. 2016.
Disruption or Excision of Provirus as an Approach to HIV Cure.. AIDS patient care and STDs.. 2016.
Human Metapneumovirus Infections following Hematopoietic Cell Transplantation: Factors Associated with Disease Progression.. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.. 2016.
Bloodborne Viral Pathogen Contamination in the Era of Laboratory Automation.. Clinical chemistry.. 2016.
Cytomegalovirus viral load and mortality after haemopoietic stem cell transplantation in the era of pre-emptive therapy: a retrospective cohort study.. The Lancet. Haematology. 3(3):e119-27.. 2016.
Comparison of enzyme immunoassays for detection of antibodies to hepatitis D virus in serum.. Clinical and vaccine immunology : CVI.. 2016.
Genome editing and the next generation of antiviral therapy.. Human genetics.. 2016.
Cell and gene therapy strategies to eradicate HIV reservoirs.. Current opinion in HIV and AIDS. 11(4):442-449.. 2016.
Prospective characterization of the risk factors for transmission and symptoms of primary human herpesvirus infections among Ugandan infants.. The Journal of infectious diseases.. 2016.
Efficient identification of inherited chromosomally integrated human herpesvirus 6 using specimen pooling.. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 77:71-76.. 2016.
A MULTICENTER, LONGITUDINAL, INTERVENTIONAL, DOUBLE BLIND RANDOMIZED CLINICAL TRIAL IN HEMATOPOIETIC CELL TRANSPLANT RECIPIENTS RESIDING IN REMOTE AREAS: LESSONS LEARNED FROM THE LATE CYTOMEGALOVIRUS PREVENTION TRIAL.. Contemporary clinical trials communications. 4:84-89.. 2016.
Copy number heterogeneity of JC virus standards.. Journal of clinical microbiology.. 2016.
Pharmacodynamics of anti-HIV gene therapy using viral vectors and targeted endonucleases.. The Journal of antimicrobial chemotherapy.. 2016.
A curative regimen would decrease HIV prevalence but not HIV incidence unless targeted to an ART-naïve population.. Scientific reports. 6:22183.. 2016.
Digital detection of endonuclease mediated gene disruption in the HIV provirus.. Scientific reports. 6:20064.. 2016.
Draft Genome Sequence of Goose Dicistrovirus.. Genome announcements. 4(2). 2016.