Nicole Frahm

Appointments and Affiliations

Fred Hutchinson Cancer Research Center
Clinical Research Division
Vaccine and Infectious Disease Institute
Member, Appointed: 2014
University of Washington
School of Public Health and Community Medicine
Department of Global Health
Assistant Professor, Appointed: 2008
Professional Headshot of Nicole  Frahm

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Ave. N.
Seattle, Washington 98109-1024
United States


Phone: (206) 667-6268


Ph.D., University of Hamburg, Germany, Immunology, 2003.
M.S., University of Braunschweig, Germany, Study of Biotechnology, 1996.

Research Interests

My research addresses the influence of HIV sequence diversity on its recognition by cytotoxic T lymphocytes, as well as the factors governing the recognition of sequence variants both in HIV-infected subjects and in vaccine trial participants. More recently, my research also includes the assessment of immune responses to viral vectors used as immunogens in HIV vaccine trials to help understand how pre-existing cellular immunity to the vector influences the quality of vaccine-induced immune responses. In my role as the Associate Laboratory Director for the HVTN, I provide leadership and scientific support for the HVTN Laboratories. This includes (but is not restricted to) oversight of the Endpoints Laboratory, which is responsible for the generation of validated immunogenicity data for all HVTN trials, and of the R&D Laboratory, which provides ancillary and exploratory data leading to a more complete view of the immune responses generated by HIV vaccines.


(Reading, Writing, Speaking)

German: (Fluent, Fluent, Fluent)
Portuguese (Brazilian): (Fluent, Fluent, Fluent)

Previous Positions

2008-2013, Assistant member, Fred Hutchinson Cancer Research Center, Clinical Research Division and Vaccine and Infectious Disease Division
2006-2008, Instructor, Harvard University, Medical School
2006-2008, Assistant in Immunology, Massachusetts General Hospital, Partners AIDS Research Center, Infectious Diseases
2001-2006, Post-doctoral fellow, Harvard University, Medical School
2001-2006, Post-doctoral fellow, Massachusetts General Hospital, Partners AIDS Research Center, Infectious Diseases


Recent Publications