Anneclaire J. De Roos
Ph.D., University of North Carolina at Chapel Hill, Epidemiology, 2000.
M.P.H., University of California, Berkeley, Epidemiology/Biostatistics, 1995.
B.A., University of California, Los Angeles, Geography, 1990.
Dr. De Roos' research interests and experience are primarily in occupational and environmental exposures to chemicals and radiation as risk factors for cancer, other chronic diseases, and intermediate biologic effects. She has conducted studies of lymphomas, leukemias, autoimmune diseases, childhood cancers, and adult brain tumors.
A focus of Dr. De Roos' research is in health effects of exposure to persistent organic pollutants (POPs). In a study of POPs in plasma as contributors to non-Hodgkin lymphoma (NHL) risk (Cancer Res, 2005), Dr. De Roos and colleagues found that certain moderate- and highly-chlorinated polychlorinated biphenyl (PCB) congeners were associated with two- to three-fold increased risk of NHL (comparing extreme quartiles). The dioxin-like furan compounds measured were also strongly associated with NHL incidence, with a significant trend across quartiles (p=0.006), and the toxic equivalency quotient (TEQ), a summed metric that weights congeners by their dioxin-like potency, was associated with 35% increased risk of NHL per 10 TEQ units. These results suggest that exposures to POPs, particularly dioxin-like POPs and certain non-dioxin-like PCBs, contribute to NHL risk. Dr. De Roos is currently investigating how PCB concentrations change during weight loss in a group of women participating in an exercise intervention trial, and how PCBs may affect immune function in these women.
Dr. De Roos is investigating environmental and occupational exposures in relation to lymphohematopoietic cancers in the Women's Health Initiative (WHI) study, including insecticide exposures and farming history. A possible mechanism by which environmental exposures may contribute to NHL risk is by affecting the immune system, either through immune suppression or B-cell activation and proliferation. In a case-control study nested within the WHI Observational Study, Dr. De Roos is investigating viral and immune markers in prediagnostic biologic samples as predictors of incident NHL. Markers of interest are antibodies to Epstein-Barr virus (EBV) antigens, circulating EBV DNA, and cytokines and other molecules involved in B-lymphocyte response, including IL6, IL10, TNFα, sCD23, sCD27, sCD30, sCD44, and CXCL13.
Several of Dr. De Roos' studies are exploring the use of geographic information systems and geographically-referenced environmental surveillance data to estimate individual-level exposures. One project focuses on environmental exposure to industrial pollution in relation to NHL risk, using data on industry locations, reported emissions, and census data. In another study, Dr. De Roos and investigators at the University of British Columbia are characterizing the possible role of air pollution in the incidence and exacerbation of rheumatoid arthritis in the Vancouver metropolitan region.
International Society for Environmental Epidemiology
Honors and Awards
2001-2001, Intramural Research Award, Division of Cancer Epidemiology and Genetics, National Cancer Institute
2000-2000, Delta Omega National Honor Society in Public Health, Delta Omega National Honor Society
2003-2009, Assistant Professor, University of Washington, School of Public Health, Department of Epidemiology
2003-2008, Assistant Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Program in Epidemiology
2000-2002, Postdoctoral Fellow, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch
1990-1992, Environmental Scientist, AeroVironment, Inc.
A meta-analysis of multiple myeloma risk regions in African and European ancestry populations identifies putatively functional loci.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.. 2016.
Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA).. Journal of epidemiology and community health.. 2016.
A Birth Cohort Study of Maternal and Infant Serum PCB-153 and DDE Concentrations and Responses to Infant Tuberculosis Vaccination.. Environmental health perspectives. 124(6):813-21.. 2016.
Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes.. Human molecular genetics. 25(8):1663-76.. 2016.
Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.. Nature communications. 7:10933.. 2016.
Associations of non-Hodgkin Lymphoma (NHL) risk with autoimmune conditions according to putative NHL loci.. American journal of epidemiology. 181(6):406-21.. 2015.
A pooled analysis of cigarette smoking and risk of multiple myeloma from the international multiple myeloma consortium.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 24(3):631-4.. 2015.
A genome-wide association study of marginal zone lymphoma shows association to the HLA region.. Nature communications. 6:5751.. 2015.
Plasma polychlorinated biphenyl concentrations and immune function in postmenopausal women.. Environmental research. 131C:174-180.. 2014.
Cytokines in serum in relation to future non-Hodgkin lymphoma risk: Evidence for associations by histologic subtype.. International journal of cancer. Journal international du cancer. 135(4):913-22.. 2014.
Environmental determinants of polychlorinated biphenyl concentrations in residential carpet dust.. Environmental science & technology. 47(18):10405-14.. 2013.
A pooled analysis of alcohol consumption and risk of multiple myeloma in the international multiple myeloma consortium.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 22(9):1620-7.. 2013.
Multiple myeloma and occupation: a pooled analysis by the International Multiple Myeloma Consortium.. Cancer epidemiology. 37(3):300-5.. 2013.
Phthalates and risk of endometriosis.. Environmental research.. 2013.
Smoking, variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma: a pooled analysis within the InterLymph consortium.. Cancer causes & control : CCC. 24(1):125-34.. 2013.
Evaluation of seasonality in the diagnosis of acute myeloid leukaemia among adults in the United States, 1992-2008.. British journal of haematology. 160(3):343-50.. 2013.
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.. Nature genetics. 45(8):868-76.. 2013.
Organochlorine Pesticides and Risk of Endometriosis: Findings from a Population-Based Case-Control Study.. Environmental health perspectives. 121(11-12):1319-1324.. 2013.
Associations between allergies and risk of hematologic malignancies:Results from the VITamins and lifestyle (VITAL) cohort study.. American journal of hematology. 88(12):1050-4.. 2013.
Investigation of Epstein-Barr Virus as a Potential Cause of B-Cell Non-Hodgkin Lymphoma in a Prospective Cohort.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 22(10):1747-55.. 2013.
Adiposity, body composition, and weight change in relation to organochlorine pollutant plasma concentrations.. Journal of exposure science & environmental epidemiology.. 2012.