Jason H. Bielas
Postdoctoral Fellow, University of Washington, The Joseph Gottstein Memorial Cancer Research Laboratory, 2006.
Ph.D., York University, Genetics, 2004.
The Bielas lab studies (http://labs.fhcrc.org/bielas) the fundamental and clinical implications of nuclear and mitochondrial DNA mutations in the pathogenesis of cancer and age-related disease.
Honors and Awards
2010-2015, Outstanding New Environmental Scientist (ONES) Award, National Institute of Environmental Health Sciences (NIEHS)
2009-2013, New Scholar Award in Aging, The Ellison Medical Foundation
2007-2010, Terry Fox Foundation Postdoctoral Research Fellowship, National Cancer Institute of Canada (NCIC)
2006-2007, Postdoctoral Fellowship, Canadian Institutes of Health Research (CIHR)
2004-2005, Postdoctoral Fellowship, Natural Sciences and Engineering Research Council of Canada (NSERC)
2004, Gold Medal, Governor General's Academic Medal, Her Excellency the Right Honourable Adrienne Clarkson, Governor General of Canada
2003, Scholarship, Haynes Scholarship for Academic Excellence in Doctoral Studies
2002-2003, Scholarship, Ontario Graduate Scholarship in Science and Technology
2001, Graduate Fellowship, International Association of Environmental Mutagen Societies
2000-2002, Graduate Scholarship, Natural Sciences and Engineering Research Council of Canada (NSERC)
2000, Dean's Academic Excellence Scholarship, Faculty of Graduate Studies, York University
2000, Health Science International Award, CANTOX
1999-2000, Scholarship, Ontario Graduate Scholarship (OGS)
1998-1999, Graduate Fellowship, Cancer Research Society Inc.
2006-2008, Acting Instructor, University of Washington, School of Medicine, Department of Pathology
Massively parallel digital transcriptional profiling of single cells.. Nature communications. 8:14049.. 2017.
Editorial overview: Molecular and genetic bases of disease.. Current opinion in genetics & development.. 2016.
Mitochondrial DNA exhibits resistance to induced point and deletion mutations.. Nucleic acids research.. 2016.
Cells Comprising the Prostate Cancer Microenvironment Lack Recurrent Clonal Somatic Genomic Aberrations.. Molecular cancer research : MCR. 14(4):347-84.. 2016.
Targeted single molecule mutation detection with massively parallel sequencing.. Nucleic acids research.. 2015.
Skeletal muscle mitochondrial DNA deletions are not increased in CuZn-superoxide dismutase deficient mice.. Experimental gerontology. 61:15-9.. 2015.
Epithelial mesenchymal-like transition occurs in a subset of cells in castration resistant prostate cancer bone metastases.. Clinical & experimental metastasis.. 2015.
The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition.. Nature cell biology. 17(12):1523-1535.. 2015.
Response to: 'when man got his mtDNA deletions?' Aging cell.. 2014.
Heterogeneity of tumor-induced gene expression changes in the human metabolic network.. Nature biotechnology. 31(6):522-529.. 2013.
Digital genomic quantification of tumor-infiltrating lymphocytes.. Science translational medicine. 5(214):214ra169.. 2013.
Decreased mitochondrial DNA mutagenesis in human colorectal cancer.. PLoS genetics. 8(6):e1002689.. 2012.
Roles of DNA polymerase I in leading and lagging-strand replication defined by a high-resolution mutation footprint of ColE1 plasmid replication.. Nucleic acids research. 39(16):7020-7033.. 2011.
Aging neural progenitor cells have decreased mitochondrial content and lower oxidative metabolism.. The Journal of biological chemistry. 286(44):38592-601.. 2011.
A random mutation capture assay to detect genomic point mutations in mouse tissue.. Nucleic acids research. 39(11):e73.. 2011.
Generation, function, and prognostic utility of somatic mitochondrial DNA mutations in cancer.. Environmental and molecular mutagenesis. 51(5):427-39.. 2010.
Molecularly evolved thymidylate synthase inhibits 5-fluorodeoxyuridine toxicity in human hematopoietic cells.. Human gene therapy. 20(12):1703-7.. 2009.